Evidence map›Paper›PMID 29116473›Full record

ReviewCurrent atherosclerosis reports2017

Early Rehabilitation After Stroke: a Narrative Review.

Elisheva R Coleman, Rohitha Moudgal, Kathryn Lang, Hyacinth I Hyacinth, Oluwole O Awosika, Brett M Kissela, Wuwei Feng

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current atherosclerosis reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06576466 (Effect of Supplementation With Creatine on the Early Recovery of Ischemic Stroke), which is not on this map. Cited by 192 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06576466 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Supplementation With Creatine on the Early Recovery of Ischemic Stroke: A Randomized Clinical Trial

TypeinterventionalSponsorFundació d'investigació Sanitària de les Illes BalearsRan2024 to 2027Enrolled92ConditionsStroke, IschemicArmsCreatine monohydrate, Placebo
3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 16 syntheses or guidelines pooled it.

  1. Combined transcranial direct current stimulation and mirror therapy for upper limb rehabilitation in patients with stroke: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  13. Positive airway pressure therapy for post-stroke sleep disordered breathing: a systematic review, meta-analysis and meta-regression.European respiratory review : an official journal of the European Respiratory Society · 2023
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132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elisheva R ColemanDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati Gardner Neuroscience Institute, 260 Stetson St., Suite 2300, Cincinnati, OH, 45267-0525, USA. colemaev@ucmail.uc.edu.
Rohitha MoudgalUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kathryn LangDepartment of Rehabilitation Services, University of Cincinnati, Cincinnati, OH, USA.
Hyacinth I HyacinthAflac Cancer and Blood Disorder Center of Children's Healthcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA, USA.
Oluwole O AwosikaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati Gardner Neuroscience Institute, 260 Stetson St., Suite 2300, Cincinnati, OH, 45267-0525, USA.
Brett M KisselaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati Gardner Neuroscience Institute, 260 Stetson St., Suite 2300, Cincinnati, OH, 45267-0525, USA.
Wuwei FengDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Cerebrovascular Fellowship Training ProgramT32NS047996 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Stacie Demel · 2006 to 2026
$3.7M
Mechanism of cerebral vaculopathy and stroke in sickle cell diseaseR01HL138423 · NHLBI · UNIVERSITY OF CINCINNATI · PI HYACINTH, HYACINTH IDU · 2017 to 2021
$2.5M
NHLBI NIH HHS R01 HL138423NIGMS NIH HHS P20 GM109040NINDS NIH HHS T32 NS047996
6 · The paper itself

Abstract

purpose of reviewDespite current rehabilitative strategies, stroke remains a leading cause of disability in the USA. There is a window of enhanced neuroplasticity early after stroke, during which the brain's dynamic response to injury is heightened and rehabilitation might be particularly effective. This review summarizes the evidence of the existence of this plastic window, and the evidence regarding safety and efficacy of early rehabilitative strategies for several stroke domain-specific deficits. RECENT

findingsOverall, trials of rehabilitation in the first 2 weeks after stroke are scarce. In the realm of very early mobilization, one large and one small trial found potential harm from mobilizing patients within the first 24 h after stroke, and only one small trial found benefit in doing so. For the upper extremity, constraint-induced movement therapy appears to have benefit when started within 2 weeks of stroke. Evidence for non-invasive brain stimulation in the acute period remains scant and inconclusive. For aphasia, the evidence is mixed, but intensive early therapy might be of benefit for patients with severe aphasia. Mirror therapy begun early after stroke shows promise for the alleviation of neglect. Novel approaches to treating dysphagia early after stroke appear promising, but the high rate of spontaneous improvement makes their benefit difficult to gauge. The optimal time to begin rehabilitation after a stroke remains unsettled, though the evidence is mounting that for at least some deficits, initiation of rehabilitative strategies within the first 2 weeks of stroke is beneficial. Commencing intensive therapy in the first 24 h may be harmful.

Indexed as

AnimalsBrainClinical Trials as TopicDisease Models, AnimalHumansNeuronal PlasticityPhysical Therapy ModalitiesRecovery of FunctionStrokeStroke RehabilitationTime FactorsAphasiaEarly rehabilitationMotor recoveryNeuroplasticityStroke recoveryStroke rehabilitation

Identifiers

PMID29116473
PMCPMC5802378

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.