Evidence map›Paper›PMID 29116394›Full record

Trial reportWorld journal of urology2018

A prospective randomized pilot study evaluating an ERAS protocol versus a standard protocol for patients treated with radical cystectomy and urinary diversion for bladder cancer.

Sebastian Karl Frees, Jonathan Aning, Peter Black, Werner Struss, Robert Bell, Claudia Chavez-Munoz, Martin Gleave, Alan I So

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 8 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 8 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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  12. Observational
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  19. Examining the impact of postoperative opioid use on length of hospital stay following radical cystectomy.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sebastian Karl FreesDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Jonathan AningDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Peter BlackDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Werner StrussDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Robert BellDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Claudia Chavez-MunozDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Martin GleaveDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Alan I SoDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada. dralanso@mail.ubc.ca.ORCID http://orcid.org/0000-0001-6465-057X
University of British Columbia · CAUniversity of British Columbia Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is a lack of evidence demonstrating the benefits of using enhanced recovery after surgery protocols (ERAS). Here, we propose to use a randomized clinical pilot study to demonstrate the benefits and feasibility of implementing ERAS versus standard protocols (SP) in patients undergoing radical cystectomy (RC) and urinary diversion.

methods27 consecutive patients undergoing RC were included in the study. 12 patients were prospectively randomized to follow an ERAS protocol and 15 patients followed an SP. Duration of hospital stay, time to first flatulence and bowel movement, complications and 30 day readmission rates, as well as subjective outcomes such as postoperative pain, nausea, bowel symptoms, quality of life (QoL), and patient experience and satisfaction were evaluated.

resultsPatients following ERAS had a significantly shorter: hospital stay, time to flatulence, and time to bowel movement than patients following SP. No major complications were reported. Only one patient in the ERAS group was readmitted for bowel obstruction, and no patients were readmitted in the SP group. Patients under ERAS reported lower postoperative pain scores. Mean Functional Assessment of Cancer Therapy Bladder Cancer score decreased and mean Expanded Prostate Cancer Index Composite, bowel symptom score increased in the SP group at the time of discharge compared to prior to surgery.

conclusionsThis study shows the feasibility of a randomized pilot study assessing ERAS compared to SP post RC. ERAS protocol provided evidence of significant benefits over SP with similar complication rates. This study suggests the need for a clinical trial of assessing ERAS protocols after RC.

Indexed as

AgedAged, 80 and overCarcinoma, Transitional CellClinical ProtocolsCystectomyFemaleFlatulenceHumansLength of StayMaleMiddle AgedPain MeasurementPatient ReadmissionPatient SatisfactionPerioperative CarePilot ProjectsBladder cancerCystectomyERASOutcomesUrinary diversion

Identifiers

PMID29116394
OpenAlexW2767506572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.