ArticleSao Paulo medical journal = Revista paulista de medicina
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study.
Article in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Evaluation of body mass index, waist-to-hip ratio, and waist-to-height ratio as predictors of insulin resistance in Syrian adult women: A cross-sectional study.The Journal of international medical research · 2026Article
- Observational
- Association between waist-to-height ratio and cardiovascular events in patients with chronic obstructive pulmonary disease: the mediating effect of prognostic nutritional index.BMC cardiovascular disorders · 2025Article
- Genetic insights of waist-to-height ratio on the risk of steatotic and advanced liver diseases: genome-wide association study and polygenic risk score-based analyses.Human genomics · 2025Article
- Left Ventricular Systolic Function in Asymptomatic Men Aged 65-75 Years, Relation to Insulin Resistance and Pre-Diabetes: A DANCAVAS Cross-Sectional Sub-Study.Journal of cardiovascular development and disease · 2025Article
- A 6-Month mHealth Low-Carbohydrate Dietary Intervention Ameliorates Glycaemic and Cardiometabolic Risk Profile in People with Type 2 Diabetes.Nutrients · 2025Article
- Prevalence and determinants of insulin resistance in recovered COVID-19 and uninfected residents of two regional capitals in Ghana: An observational study.PLOS global public health · 2025Article
- Biomarkers and Data Visualization of Insulin Resistance and Metabolic Syndrome: An Applicable Approach.Life (Basel, Switzerland) · 2024Article
- Novel anthropometric indices for predicting type 2 diabetes mellitus.BMC public health · 2024Article
- Surrogate indices of insulin resistance using the Matsuda index as reference in adult men-a computational approach.Frontiers in endocrinology · 2024Article
- The waist-to-height ratio is a good predictor for insulin resistance in women with polycystic ovary syndrome.Frontiers in endocrinology · 2024Article
- Waist-to-height ratio associated cardiometabolic risk phenotype in children with overweight/obesity.BMC public health · 2023Article
- Appropriate neck circumference and waist-to-height ratio cut-off points as predictors of obesity and cardiovascular risk in adolescents.Revista de saude publica · 2023Article
- Disparity in association of obesity measures with ankle and brachial systolic blood pressures in Europeans and South Asians.Scientific reports · 2022Article
- Prediction of gestational diabetes mellitus by different obesity indices.BMC pregnancy and childbirth · 2022Article
- Article
- Circulating IL-6, clusterin and irisin in obese subjects with different grades of obesity: association with insulin resistance and sexual dimorphism.Archives of endocrinology and metabolism · 2021Article
- Impact of Sociodemographic Characteristics, Lifestyle, and Obesity on Coexistence of Diabetes and Hypertension: A Structural Equation Model Analysis amongst Chinese Adults.International journal of hypertension · 2021Article
- Abnormal Glucose Metabolism and Associated Risk Factors Among Adults in Mekelle City, Ethiopia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin resistance (IR) and progressive pancreatic β-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in non-diabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND
settingCross-sectional study conducted in a private clinic.
methodsWe included obese individuals (body mass index, BMI ≥ 30 kg/m2) with no diabetes mellitus (fasting glucose levels ≤ 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-β indexes. The area underthe curve (AUC) of the variables was compared.The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated.
resultsThe most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-β and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-β, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73).The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-β.
conclusionAmong anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals.
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