ArticleScientific reports2017
Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Multicomponent Synthesis of C(8)-Substituted Purine Building Blocks of Peptide Nucleic Acids from Prebiotic Compounds.ChemistryOpen · 2024Article
- Multicomponent Synthesis of Diaminopurine and Guanine PNA's Analogues Active against Influenza A Virus from Prebiotic Compounds.ACS omega · 2022Article
- Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity.RSC advances · 2021Article
- Meteorite-catalyzed intermolecularRSC advances · 2021Article
- 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.Nature communications · 2021Article
- Prebiotic Organic Chemistry of Formamide and the Origin of Life in Planetary Conditions: What We Know and What Is the Future.International journal of molecular sciences · 2021Review
- Astrochemistry and Astrobiology: Materials Sciencein Wonderland?International journal of molecular sciences · 2019Review
- A Universal Geochemical Scenario for Formamide Condensation and Prebiotic Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Review
- Chemomimesis and Molecular Darwinism in Action: From Abiotic Generation of Nucleobases to Nucleosides and RNA.Life (Basel, Switzerland) · 2018Review
- The Prevailing Catalytic Role of Meteorites in Formamide Prebiotic Processes.Life (Basel, Switzerland) · 2018Review
- Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis.Nature communications · 2018Article
- Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2021-2022.Mass spectrometry reviewsReview
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the pathway of a general reaction leading to the one-pot synthesis of ribo- and 2'-deoxy-ribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite. These conditions simulate the presumptive conditions in space or on an early Earth fluxed by slow protons from the solar wind, potentially mimicking a plausible prebiotic scenario. The reaction (i) requires neither pre-activated precursors nor intermediate purification/concentration steps, (ii) is based on a defined radical mechanism, and (iii) is characterized by stereoselectivity, regioselectivity and (poly)glycosylation. The yield is enhanced by formamide and meteorite relative to the control reaction.
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