ArticleScientific reports2017
Sniffer mice discriminate urine odours of patients with bladder cancer: A proof-of-principle study for non-invasive diagnosis of cancer-induced odours.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review.Integrative cancer therapiesPooled it
- A standardized lexicon of body odor words crafted from 17 countries.Scientific data · 2025Article
- Partial role of volatile organic compounds in behavioural responses of mice to bedding from cancer-affected congeners.Biology open · 2024Article
- Worm-Based Diagnosis Combining Microfluidics toward Early Cancer Screening.Micromachines · 2024Review
- Changes in the urine volatile metabolome throughout growth of transplanted hepatocarcinoma.Scientific reports · 2022Article
- Odours of cancerous mouse congeners: detection and attractiveness.Biology open · 2022Article
- Hierarchical Elemental Odor Coding for Fine Discrimination Between Enantiomer Odors or Cancer-Characteristic Odors.Frontiers in behavioral neuroscience · 2022Review
- ABiology open · 2021Article
- Electronic nose to distinguish bladder cancer by urinary odour feature: A pilot study.Cancer biomarkers : section A of Disease markers · 2020Article
- Sharing an environment with sick conspecifics alters odors of healthy animals.Scientific reports · 2018Article
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Similar to fingerprints, humans have unique, genetically determined body odours. In case of urine, the odour can change due to variations in diet as well as upon infection or tumour formation. We investigated the use of mice in a manner similar to "sniffer dogs" to detect changes in urine odour in patients with bladder cancer. We measured the odour discrimination thresholds of mice in a Y-maze, using urine mixtures from patients with bladder cancer (Stage I) and healthy volunteers (dietary variations) as well as occult blood- or antibiotic drug metabolite-modulated samples. Threshold difference indicated that intensities of urinary olfactory cues increase in the following order: dietary variation < bladder cancer < occult blood < antibiotic drug metabolites. After training with patient urine mixtures, sniffer mice discriminated between urine odours of pre- and post-transurethral resection in individual patients with bladder cancer in an equal-occult blood diluted condition below the detection level of dietary variations, achieving a success rate of 100% (11/11). Furthermore, genetic ablation of all dorsal olfactory receptors elevated the discrimination thresholds of mice by ≥ 10
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