ArticleScientific reports2017
Risk Factors and Molecular Features of Sequence Type (ST) 131 Extended-spectrum β-Lactamase-producing Escherichia coli in Community-onset Bacteremia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 23 citations in OpenAlex.
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- Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections.PloS one · 2023Article
- Duration of rectal colonization with extended-spectrum beta-lactamase-producing Escherichia coli: results of an open, dynamic cohort study in Dutch nursing home residents (2013-2019).Antimicrobial resistance and infection control · 2022Article
- From Pathophysiological Hypotheses to Case-Control Study Design: Resistance from Antibiotic Exposure in Community-Onset Infections.Antibiotics (Basel, Switzerland) · 2022Article
- Predominance of genetically diverse ESBL Escherichia coli identified in resistance mapping of Vembanad Lake, the largest fresh-cum-brackishwater lake of India.Environmental science and pollution research international · 2021Article
- Risk Factors for Extended-Spectrum-β-Lactamase-ProducingAnnals of laboratory medicine · 2021Article
- Prevalence and Molecular Epidemiology of Extended-Spectrum-β-Lactamase (ESBL)-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Distribution of ciprofloxacin-resistance genes among ST131 and non-ST131 clones ofIranian journal of microbiology · 2021Article
- Prevalence and Molecular Epidemiology of Extended-Spectrum-β-Lactamase (ESBL)-ProducingAnnals of laboratory medicine · 2021Article
- Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community.Scientific reports · 2021Article
- Molecular epidemiology of antimicrobial resistant microorganisms in the 21th century: a review of the literature.Acta bio-medica : Atenei Parmensis · 2020Review
- Clinically Relevant Extended-Spectrum β-Lactamase-ProducingFrontiers in microbiology · 2020Article
- [Bloodstream infections withNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Source Attribution and Risk Assessment of Antimicrobial Resistance.Microbiology spectrum · 2018Review
- Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea.The Korean journal of internal medicine · 2018Review
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6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the spread of a single CTX-M-type extended-spectrum β-lactamase (ESBL) clone of sequence type (ST) 131, community-onset bacteremia caused by ESBL-producing Escherichia coli has increased dramatically. We evaluated the risk factors and molecular features of ESBL-producing E. coli ST131 clones isolated from Korean patients with community-onset bacteremia. We collected a total of 124 ESBL-producing E. coli isolates from blood in patients with community-onset bacteremia over a 2 year-period. Among 124 patients, the number of community-associated bacteremia cases was 57 (46%). ST131 strains accounted for 49.1% (28/57) of community-associated bacteremia cases and 44.8% (30/67) of healthcare-associated community-onset bacteremia cases. Among 58 ST131 strains, nine isolates were shown to harbor O16-H41, and 61.1% (30/49) of O25 had H30Rx. In a multivariate analysis, independent risk factors for acquisition of ST131 isolates over non-ST131 isolates were underlying diabetes mellitus and absence of prior chemotherapy history. The most common ESBL genotype was CTX-M-15 (46.0%), followed by CTX-M-14 (37.1%). A considerable proportion of community-onset ESBL-producing E. coli bacteremia was observed. ST131 clones appear to be associated with the spread of community-associated bacteremia exhibiting high antimicrobial resistance and highly virulent H30Rx traits, which could become a major public health concern in Korea.
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