ArticleNature communications2017
Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Management of the devastating pest of potato Phthorimaea operculella Zeller (Lepidoptera: Gelechiidae) through oviposition deterrent.Pest management science · 2026Article
- SNMP1 Contributes to Sensitive Pheromone and Plant Volatile Detection in the Locust Olfactory System.International journal of molecular sciences · 2026Article
- Boosting Artificial Olfaction: Visual Cues-Enhanced Gas Classification by a Bimodal Neuromorphic Device.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Article
- Simultaneous recording of spikes and calcium signals in odor-evoked responses ofJournal of neurogenetics · 2025Article
- Article
- Targeted deletion of olfactory receptors inJournal of neurogenetics · 2024Article
- Olfactory sensitivity differentiates morphologically distinct worker castes in Camponotus floridanus.BMC biology · 2023Article
- Odorant inhibition in mosquito olfaction mediated by inverse agonists.Biochemical and biophysical research communications · 2022Article
- Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type.PLoS biology · 2022Article
- Mosquito odorant receptor sensitive to natural spatial repellents and inhibitory compounds.Insect biochemistry and molecular biology · 2022Article
- Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity.Molecular biology reports · 2021Article
- Organization and emergence of a mixed GABA-glycine retinal circuit that provides inhibition to mouse ON-sustained alpha retinal ganglion cells.Cell reports · 2021Article
- Flies Avoid Current Atmospheric COFrontiers in physiology · 2021Article
- Functional properties of insect olfactory receptors: ionotropic receptors and odorant receptors.Cell and tissue research · 2021Review
- The Olfactory Chemosensation of Hematophagous Hemipteran Insects.Frontiers in physiology · 2021Review
- Evolution, developmental expression and function of odorant receptors in insects.The Journal of experimental biology · 2020Review
- Scaling the interactive effects of attractive and repellent odours for insect search behaviour.Scientific reports · 2019Article
- Optimal compressed sensing strategies for an array of nonlinear olfactory receptor neurons with and without spontaneous activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Odorant Inhibition in Mosquito Olfaction.iScience · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Inhibitory response occurs throughout the nervous system, including the peripheral olfactory system. While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the molecular mechanism and functional roles of odor-evoked inhibition remain largely unknown. Here, we examined Drosophila olfactory sensory neurons and found that inhibitory odors triggered outward receptor currents by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in olfactory sensory neurons. Remarkably, this odor-evoked inhibition of olfactory sensory neurons elicited by itself a full range of olfactory behaviors from attraction to avoidance, as did odor-evoked olfactory sensory neuron excitation. These results indicated that peripheral inhibition is comparable to excitation in encoding sensory signals rather than merely regulating excitation. Furthermore, we demonstrated that a bidirectional code with both odor-evoked inhibition and excitation in single olfactory sensory neurons increases the odor-coding capacity, providing a means of efficient sensory encoding.
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