Evidence map›Paper›PMID 29115985›Full record

ArticleBMC research notes2017

Use of tuberculin skin test for assessment of immune recovery among previously malnourished children in Ethiopia.

Paluku Bahwere, Philip James, Alemseged Abdissa, Yesufe Getu, Yilak Getnet, Kate Sadler, Tsinuel Girma

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Paluku BahwereValid International, 35, Leopold Street, Oxford, OX4 1TW, UK. paluku@validinternational.org.ORCID http://orcid.org/0000-0003-2781-965X
Philip JamesValid International, 35, Leopold Street, Oxford, OX4 1TW, UK.
Alemseged AbdissaDepartment of Medical Laboratory Sciences and Pathology, Jimma University, Jimma, Oromia, Ethiopia.
Yesufe GetuSave Children Federation, Addis Ababa, Ethiopia.
Yilak GetnetSave Children Federation, Addis Ababa, Ethiopia.
Kate SadlerValid International, 35, Leopold Street, Oxford, OX4 1TW, UK.
Tsinuel GirmaDepartment of Paediatrics and Child Health, Jimma University, Jimma, Oromia, Ethiopia.
International Trachoma Initiative · ETJimma University · ETValid International (United Kingdom) · GBLondon School of Hygiene & Tropical Medicine · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare levels of immunity in children recovering from severe acute malnutrition (cases) against those of community controls (controls).

resultsAt baseline children recovering from severe acute malnutrition had lower, mid upper arm circumference (122 mm for cases and 135 mm for controls; p < 0.001), weight-for-height Z-score (- 1.0 for cases and - 0.5 for controls; p < 0.001), weight-for-age Z-score (- 2.8 for cases and - 1.1 for controls; p < 0.001) and height/length-for-age Z-score (- 3.6 for cases and - 1.4 for controls; p < 0.001), than controls. Age and gender matched community controls. At baseline, prevalence of a positive tuberculin skin test, assessed by cutaneous delayed-type hypersensitivity reaction skin test, was very low in both cases (3/93 = 3.2%) and controls (2/94 = 2.1%) and did not significantly increase at 6 months follow up (6/86 = 7.0% in cases and 3/84 = 3.4% in controls). The incidences of common childhood morbidities, namely fever, diarrhoea and cough, were 1.7-1.8 times higher among cases than controls. In conclusion, these results show that tuberculin skin test does not enable any conclusive statements regarding the immune status of patients following treatment for severe acute malnutrition. The increased incidence of infection in cases compared to controls suggests persistence of lower resistance to infection even after anthropometric recovery is achieved.

Indexed as

Body SizeAftercareChild Nutrition DisordersChild, PreschoolEthiopiaFemaleHumansInfantMaleSeverity of Illness IndexTuberculin TestCommunity-based management of acute malnutritionDelayed-type hypersensitivity responseImmunityMorbiditySevere acute malnutritionTuberculin purified protein derivativeTuberculin skin test

Identifiers

PMID29115985
PMCPMC5688824
OpenAlexW2767831906

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.