Evidence map›Paper›PMID 29115971›Full record

ArticleBMC veterinary research2017

Local anaesthetics or their combination with morphine and/or magnesium sulphate are toxic for equine chondrocytes and synoviocytes in vitro.

L M Rubio-Martínez, E Rioja, M Castro Martins, S Wipawee, P Clegg, M J Peffers

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

L M Rubio-MartínezInstitute of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, CH647TE, Neston, UK. luis.rubiomartinez@hotmail.com.
E RiojaInstitute of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, CH647TE, Neston, UK.
M Castro MartinsInstitute of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, CH647TE, Neston, UK.
S WipaweeFaculty of Veterinary Science, Rajamangala University of Technology Srivijaya (Thailand) and Institute of Aging and Chronic Disease, University of Liverpool, Liverpool, UK.
P CleggInstitute of Aging and Chronic Disease, University of Liverpool, Liverpool, UK.
M J PeffersInstitute of Aging and Chronic Disease, University of Liverpool, Liverpool, UK.
University of Liverpool · GBRajamangala University of Technology Srivijaya · TH

Funding

Medical Research Council MR/P020941/1Wellcome Trust
6 · The paper itself

Abstract

backgroundChondrotoxic effects of local anaesthetics are well reported in humans and some animal species but knowledge on their toxic effects on synoviocytes or equine chondrocytes or the effects on cellular production of inflammatory cytokines is limited. The purpose of this study was to evaluate the in vitro effects of local anaesthetics, morphine, magnesium sulphate (MgSO

resultsMorphine alone, MgSO

conclusionsThis in vitro study gives further evidence of the absence of cytotoxic effects of morphine alone, MgSO

Indexed as

HorsesAnesthetics, LocalAnimalsBupivacaineCell SurvivalChondrocytesCoculture TechniquesCytokinesDrug CombinationsGene ExpressionMagnesium SulfateMepivacaineMorphineSynoviocytesAnesthetics, LocalBupivacaineCytokinesDrug CombinationsMagnesium SulfateMepivacaineMorphineChondrocyteEquineLocal anaestheticMagnesium sulphateMorphineSynoviocyte

Identifiers

PMID29115971
PMCPMC5678813
OpenAlexW2767922776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.