Evidence map›Paper›PMID 29115744›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Engineering of a DNA Polymerase for Direct m

Joos Aschenbrenner, Stephan Werner, Virginie Marchand, Martina Adam, Yuri Motorin, Mark Helm, Andreas Marx

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. The importance of mRNA (New York, N.Y.) · 2023
    Article
  9. Article
  10. Biological roles of adenine methylation in RNA.Nature reviews. Genetics · 2023
    Review
  11. Absolute quantification of single-base mNature biotechnology · 2023
    Article
  12. Review
  13. Detection technologies for RNA modifications.Experimental & molecular medicine · 2022
    Review
  14. In Vitro Selection of Deoxyribozymes for the Detection of RNA Modifications.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  15. High Fidelity Enzyme-Free Primer Extension with an Ethynylpyridone Thymidine Analog.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  16. A quantitative model predicts how mNature communications · 2021
    Article
  17. Review
  18. Article
  19. Article
  20. Tag-Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases.Angewandte Chemie (International ed. in English) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Joos AschenbrennerDepartment of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstraße 10, 78457, Konstanz, Germany.
Stephan WernerInstitute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128, Mainz, Germany.
Virginie MarchandLaboratoire Ingénierie Moléculaire et Physiopathologie Articulaire, IMoPA, UMR7365 CNRS-UL, Biopôle de L'Université de Lorraine, 9, Avenue de la Forêt de Haye, 54505, Vandoeuvre-les-Nancy, France.
Martina AdamDepartment of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstraße 10, 78457, Konstanz, Germany.
Yuri MotorinLaboratoire Ingénierie Moléculaire et Physiopathologie Articulaire, IMoPA, UMR7365 CNRS-UL, Biopôle de L'Université de Lorraine, 9, Avenue de la Forêt de Haye, 54505, Vandoeuvre-les-Nancy, France.
Mark HelmInstitute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128, Mainz, Germany.
Andreas MarxDepartment of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstraße 10, 78457, Konstanz, Germany.ORCID 0000-0002-6471-3689
University of Konstanz · DECentre National de la Recherche Scientifique · FRJohannes Gutenberg University Mainz · DE

Funding

European Research Council 339834
6 · The paper itself

Abstract

Methods for the detection of RNA modifications are of fundamental importance for advancing epitranscriptomics. N

Indexed as

AdenosineDNA-Directed DNA PolymeraseDNA MethylationHigh-Throughput Nucleotide SequencingProtein EngineeringReverse Transcriptase Polymerase Chain ReactionRNA, MessengerAdenosineDNA-Directed DNA PolymeraseN-methyladenosineRNA, MessengerDNA polymerasesenzyme engineeringepitranscriptomicsN6-methyladenosineRNA modification

Identifiers

PMID29115744
PMCPMC5768020
OpenAlexW2767459859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.