ArticleMagnetic resonance in medicine2018
The effects of intravoxel contrast agent diffusion on the analysis of DCE-MRI data in realistic tissue domains.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Current status in spatiotemporal analysis of contrast-based perfusion MRI.Magnetic resonance in medicine · 2024Review
- Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Quantitative magnetic resonance imaging and tumor forecasting of breast cancer patients in the community setting.Nature protocols · 2021Review
- Patient-Specific Characterization of Breast Cancer Hemodynamics Using Image-Guided Computational Fluid Dynamics.IEEE transactions on medical imaging · 2020Article
- Optimal mass transport kinetic modeling for head and neck DCE-MRI: Initial analysis.Magnetic resonance in medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeQuantitative evaluation of dynamic contrast enhanced MRI (DCE-MRI) allows for estimating perfusion, vessel permeability, and tissue volume fractions by fitting signal intensity curves to pharmacokinetic models. These compart mental models assume rapid equilibration of contrast agent within each voxel. However, there is increasing evidence that this assumption is violated for small molecular weight gadolinium chelates. To evaluate the error introduced by this invalid assumption, we simulated DCE-MRI experiments with volume fractions computed from entire histological tumor cross-sections obtained from murine studies.
methodsA 2D finite element model of a diffusion-compensated Tofts-Kety model was developed to simulate dynamic T
resultsResults indicated parameterization errors of -19.1% ± 10.6% in K
conclusionThese results indicate a need for revising the standard model of DCE-MRI to incorporate a correction for slow diffusion of contrast agent. Magn Reson Med 80:330-340, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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