ArticleJournal of cellular physiology2018
Four differentially methylated gene pairs to predict the prognosis for early stage hepatocellular carcinoma patients.
Article in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Construction of a prognostic model based on genome-wide methylation analysis of miRNAs for hepatocellular carcinoma.Epigenomics · 2024Article
- Immune-associated molecular occurrence and prognosis predictor of hepatocellular carcinoma: an integrated analysis of GEO datasets.Bioengineered · 2021Article
- Identification of a thirteen-gene signature predicting overall survival for hepatocellular carcinoma.Bioscience reports · 2021Article
- Identification, Verification and Pathway Enrichment Analysis of Prognosis-Related Immune Genes in Patients With Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- Identification of a five-gene signature in association with overall survival for hepatocellular carcinoma.PeerJ · 2021Article
- A glycolysis-related gene signature predicts prognosis of patients with esophageal adenocarcinoma.Aging · 2020Article
- A glycolysis-related gene pairs signature predicts prognosis in patients with hepatocellular carcinoma.PeerJ · 2020Article
- A FITM1-Related Methylation Signature Predicts the Prognosis of Patients With Non-Viral Hepatocellular Carcinoma.Frontiers in genetics · 2020Article
- A Nomogram Based on a Three-Gene Signature Derived from AATF Coexpressed Genes Predicts Overall Survival of Hepatocellular Carcinoma Patients.BioMed research international · 2020Article
- A Novel Ten-Gene Signature Predicting Prognosis in Hepatocellular Carcinoma.Frontiers in cell and developmental biology · 2020Article
- Identification of a novel glycolysis-related gene signature for predicting metastasis and survival in patients with lung adenocarcinoma.Journal of translational medicine · 2019Article
- Article
- Identification of novel cell glycolysis related gene signature predicting survival in patients with endometrial cancer.Cancer cell international · 2019Article
- Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma.Cancer cell international · 2019Article
- Four differentially methylated gene pairs to predict the prognosis for early stage hepatocellular carcinoma patients.Journal of cellular physiology · 2018Article
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5 authors.
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Abstract
Hepatocellular carcinoma (HCC) was the second most common malignant tumor with a poor prognostic condition. We aimed to identify novel methylation signatures to predict HCC patients at their early stages. Differentially expressed methylated genes between HCC patients and normal liver tissues retrieved from TCGA were screened out by SAM. Genes highly related to patients' survival were figured out by COX. The signatures that could identify relapse HCC patients were identified by the forwarding search algorithm. Besides, functional enrichment analysis was performed on the methylation genes in the signature. A total of 5,392 CPG sites that differentially methylated expressed were found out and 4,294 differentially expressed genes were obtained. A total of 197 genes among were associated with RFS of HCC patients at both stage I and stage II. Signature composed of 21 pairs was obtained to predict the prognostic situation by C-index forward search method. The function of these genes was figured out by functional enrichment analysis. To summary, the signature composed of 21 gene pairs that can predict the prognostic situation of HCC patients at both stage I and stage II, provided a reference standard for the adjuvant therapy of HCC patients after surgery.
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