ArticleMolecular medicine reports2018
Two‑component histidine kinase DRK1 is required for pathogenesis in Sporothrix schenckii.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Hybrid histidine kinases and antifungal warfare in thermal dimorphic fungi.Antimicrobial agents and chemotherapy · 2026Review
- Genetic Manipulation inJournal of fungi (Basel, Switzerland) · 2026Review
- Current Insights intoJournal of fungi (Basel, Switzerland) · 2025Article
- Signaling Pathways Regulating Dimorphism in Medically Relevant Fungal Species.Pathogens (Basel, Switzerland) · 2025Review
- Polypeptides TargetingJournal of fungi (Basel, Switzerland) · 2023Article
- Insights on Covid-19 with superimposed pulmonary histoplasmosis: The possible nexus.Immunity, inflammation and disease · 2023Review
- The State of the Art in Transcriptomics and Proteomics of Clinically RelevantJournal of fungi (Basel, Switzerland) · 2023Review
- Induced Expression ofMicroorganisms · 2023Article
- Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2022Review
- Pathogenic Process-Associated Transcriptome Analysis ofInternational journal of genomics · 2022Article
- Biological and Clinical Attributes ofInfection and drug resistance · 2022Review
- Drk1, a Dimorphism Histidine Kinase, Contributes to Morphology, Virulence, and Stress Adaptation inJournal of fungi (Basel, Switzerland) · 2021Article
- Map of dimorphic switching‑related signaling pathways inMolecular medicine reports · 2021Article
- Transcriptome Analysis of Dimorphic Fungus Sporothrix schenckii Exposed to Temperature Stress.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Transcriptome-wide expression profiling ofMicrobial genomics · 2020Article
- Ste20 is crucial for dimorphic switching of sporothrix schenckii and affects its global transcriptome.International journal of clinical and experimental pathology · 2020Article
- FSH1 regulates the phenotype and pathogenicity of the pathogenic dermatophyte Microsporum canis.International journal of molecular medicine · 2019Article
- Silencing ofInfection and drug resistance · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporothrix schenckii is a pathogenic dimorphic fungus with a global distribution. It grows in a multicellular hyphal form at 25˚C and a unicellular yeast form at 37˚C. The morphological switch from mold to yeast form is obligatory for establishing pathogenicity in S. schenckii. Two‑component signaling systems are utilized by eukaryotes to sense and respond to external environmental changes. DRK1is a hybrid histidine kinase, which functions as a global regulator of dimorphism and virulence in Blastomyces dermatitidis and Histoplasma capsulatum. An intracellular soluble hybrid histidine kinase, homologous to DRK1 in B. dermatitidis, has previously been identified in S. schenckii and designated as SsDRK1. In the present study, the function of SsDRK1 was investigated using double stranded RNA interference mediated by Agrobacterium tumefaciens. SsDRK1 was demonstrated to be required for normal asexual development, yeast‑phase cell formation, cell wall composition and integrity, melanin synthesis, transcription of the morphogenesis‑associated gene Ste20 that is involved in the high osmolarity glycerol/mitogen‑activated protein kinase pathway, and pathogenicity of S. schenckii in a murine model of cutaneous infection. Further investigations into the signals SsDRK1 responds to, and the interactions of upstream transmembrane hybrid histidine kinases with SsDRK1, are required to uncover novel targets for anti‑fungal therapies.
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