ArticleInternational journal of molecular medicine2018
Cryptdin-2 predicts intestinal injury during heatstroke in mice.
Article in International journal of molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 49 citations in OpenAlex.
- Electroacupuncture in Treatment of Acute Gastrointestinal Injury in Patients with Severe Traumatic Brain Injury: A Multicenter Randomized Controlled Trial.Chinese journal of integrative medicine · 2023Trial
- Histopathological and molecular mechanisms of multi-organ damage in heat stroke: Endothelial failure, immune crosstalk, and regulated cell death pathways.Histology and histopathology · 2026Review
- DietaryAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Heatstroke-Induced Inflammatory Response and Therapeutic Biomarkers.Biomedicines · 2025Review
- Heat stroke dysfunctions: from pathophysiology to prediction.Frontiers in physiology · 2025Review
- The pathogenesis and management of heatstroke and heatstroke-induced lung injury.Burns & trauma · 2025Review
- Resveratrol Alleviates Zearalenone-Induced Intestinal Dysfunction in Mice through the NF-κB/Nrf2/HO-1 Signalling Pathway.Foods (Basel, Switzerland) · 2024Article
- Effect of supplementation withFrontiers in microbiology · 2024Article
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- Mechanisms and regulation of defensins in host defense.Signal transduction and targeted therapy · 2023Review
- The role of the gut microbiota and fecal microbiota transplantation in neuroimmune diseases.Frontiers in neurology · 2023Review
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- The Chinese Herbal Formula Huoxiang Zhengqi Dropping Pills Prevents Acute Intestinal Injury Induced by Heatstroke by Increasing the Expression of Claudin-3 in Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Prognostic value of plasma exosomal levels of histone H3 protein in patients with heat stroke.Experimental and therapeutic medicine · 2021Article
- Article
- Intestinal Microbiota and Serum Metabolic Profile Responded to Two Nutritional Different Diets in Mice.Frontiers in nutrition · 2021Article
- Clinical Characteristics and Risk Factors Associated With Acute Kidney Injury Inpatient With Exertional Heatstroke: An Over 10-Year Intensive Care Survey.Frontiers in medicine · 2021Article
- Article
- Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury.Experimental and therapeutic medicine · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal injury-induced bacterial translocation and endotoxemia are important in the pathophysiological process of heatstroke. However, the underlying mechanism remains to be fully elucidated. Previous studies using 2D-gel electrophoresis found that defensin-related cryptdin-2 (Cry-2), an intestinal α-defensin, is upregulated in intestinal tissues during heatstroke in mice, and that treatment with ulinastatin, a multivalent enzyme inhibitor, reduced heat-induced acute lung injury. To investigate the association between Cry-2 and heat stress (HS)-induced intestinal injury and the probable protective role of ulinastatin, the present study examined the intestinal expression of Cry-2 via histopathologic analysis and reverse transcription-quantitative polymerase chain reaction analysis in mice with heatstroke. The heat-stressed mice were exposed to different core temperatures and cooling treatments, and intestinal pathological changes and Chiu scores were determined. Chemical markers of intestinal injury, serum and intestinal concentrations of diamine oxidase (DAO) and D-lactic acid (D-Lac), and serum and intestinal concentrations of Cry-2 were also determined. Correlations were analyzed using Spearman's correlation analysis. It was found that HS upregulated the expression of Cry-2, and the serum and intestinal concentrations of Cry-2 were correlated with the severity of HS-induced intestinal damage, indicated by pathology scores and concentrations of DAO and D-lac. Ulinastatin protected the intestines from HS-induced injury and downregulated the expression of Cry-2, which was also correlated with the extent of intestinal injury. Therefore, ulinastatin administration may be beneficial for patients with heatstroke, and Cry-2 may be a novel predictor of HS-induced intestinal injury.
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