Evidence map›Paper›PMID 29114875›Full record

ArticleInternational journal of cancer2018

Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.

Fränzel J B van Duijnhoven, Mazda Jenab, Kristian Hveem, Peter D Siersema, Veronika Fedirko, Eric J Duell, Ellen Kampman, Anouk Halfweeg, Henk J van Kranen, Jody M W van den Ouweland and 42 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors at 20 institutions in 13 countries.

Fränzel J B van DuijnhovenNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.ORCID 0000-0001-8367-2352
Mazda JenabInternational Agency for Research on Cancer (IARC-WHO), Lyon, France.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Peter D SiersemaDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, The Netherlands.
Veronika FedirkoDepartment of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA.
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0001-5256-0163
Ellen KampmanDivision of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Anouk HalfweegDivision of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Henk J van KranenNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Jody M W van den OuwelandDepartment of Clinical Chemistry, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
Elisabete WeiderpassDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Neil MurphyInternational Agency for Research on Cancer (IARC-WHO), Lyon, France.
Arnulf LanghammerHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Eivind Ness-JensenHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Anja OlsenDanish Cancer Society Research Center, Copenhagen, Denmark.
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Kim OvervadSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus C, Denmark.
Claire CadeauUniversité Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Marina KvaskoffUniversité Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Marie-Christine Boutron-RuaultUniversité Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Verena A KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7702-317X
Heiner BoeingDepartment of Epidemiology, German Institute for Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Anastasia KotanidouHellenic Health Foundation, Athens, Greece.
Maria KritikouHellenic Health Foundation, Athens, Greece.
Domenico PalliMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.ORCID 0000-0002-5558-2437
Claudia AgnoliEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Rosario TuminoCancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital, ASP Ragusa, (Italy).
Salvatore PanicoDipartimento di medicina clinica e chirurgia, Federico II university, Naples, Italy.
Giuseppe MatulloDepartment of Medical Sciences, University of Torino, Torino, Italy.
Petra PeetersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Magritt BrustadDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Karina Standahl OlsenDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Cristina LasherasOviedo University, Asturias, Spain.
Mireia Obón-SantacanaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
María-José SánchezEscuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
Miren DorronsoroPublic Health Direction and Biodonostia-Ciberesp, Basque Regional Health Department, San Sebastian, Spain.
Maria-Dolores ChirlaqueCIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
Aurelio BarricarteCIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
Jonas ManjerDepartment of Surgery, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Martin AlmquistDepartment of Surgery, Endocrine-Sarcoma unit, Skane University Hospital, Lund, Sweden.
Frida RenströmGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Weimin YeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6859-4648
Nick WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Kay-Tee KhawUniversity of Cambridge, Cambridge, United Kingdom.
Kathryn E BradburyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-3345-7333
Heinz FreislingInternational Agency for Research on Cancer (IARC-WHO), Lyon, France.
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom.
Teresa NoratDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom.
H B As Bueno-de-MesquitaNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Centre international de recherche sur le cancer · FRImperial College London · GBNorwegian University of Science and Technology · NOUniversité Paris-Sud · FRDanish Cancer Society · DKGerman Cancer Research Center · DEInstitut d'Investigació Biomédica de Bellvitge · ESKarolinska Institutet · SELund University · SENational and Kapodistrian University of Athens · GRNational Institute for Public Health and the Environment · NLUiT The Arctic University of Norway · NOUniversity of Cambridge · GBWageningen University & Research · NLAarhus University · DKAzienda Usl 8 Arezzo · ITBasque Government · ESCanisius-Wilhelmina Ziekenhuis · NLEmory University · USFederico II University Hospital · IT

Funding

Cancer Research UK 14136Cancer Research UK 16491Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Medical Research Council G0401527Medical Research Council G0500300Medical Research Council G0800603Medical Research Council G1000143Medical Research Council MC_UU_12015/1Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1World Health Organization 001
6 · The paper itself

Abstract

Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D

Indexed as

25-Hydroxyvitamin D 2AgedCalcifediolCase-Control StudiesEuropeFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPancreatic NeoplasmsProspective StudiesRisk AssessmentSeasons25-Hydroxyvitamin D 2Calcifediolcancer epidemiologynested case-control studypancreatic cancervitamin D

Identifiers

PMID29114875
PMCPMC5813219
OpenAlexW2767883061

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.