ArticleAdvances in radiation oncology
Clinical outcomes of intensity modulated proton therapy and concurrent chemotherapy in esophageal carcinoma: a single institutional experience.
Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Efficacy and Safety in Proton Therapy and Photon Therapy for Patients With Esophageal Cancer: A Meta-Analysis.JAMA network open · 2023Pooled it
- Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Trial
- Advances in radiotherapy in the treatment of esophageal cancer.World journal of clinical oncology · 2025Article
- Feasibility study for proton dose calculation of esophageal squamous cell carcinoma based on stopping power ratio directly derived from dual energy CT.Frontiers in oncology · 2025Article
- A Prospective Pilot Study of Pencil Beam Scanning Proton Radiation Therapy as a Component of Trimodality Therapy for Esophageal Cancer.Advances in radiation oncology · 2024Article
- Esophageal Cancer Outcomes After Definitive Chemotherapy With Intensity Modulated Proton Therapy.International journal of particle therapy · 2024Article
- Proton Therapy With Concurrent Chemotherapy for Thoracic Esophageal Cancer: Toxicity, Disease Control, and Survival Outcomes.International journal of particle therapy · 2023Article
- Article
- Proton Therapy in the Management of Luminal Gastrointestinal Cancers: Esophagus, Stomach, and Anorectum.Cancers · 2022Review
- Comparison of intensity modulated proton therapy beam configurations for treating thoracic esophageal cancer.Physics and imaging in radiation oncology · 2022Article
- Dosimetric analysis and biological evaluation between proton radiotherapy and photon radiotherapy for the long target of total esophageal squamous cell carcinoma.Frontiers in oncology · 2022Article
- Current status and application of proton therapy for esophageal cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Review
- Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy From the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees.Frontiers in oncology · 2021Review
- Proton beam radiotherapy for esophagus cancer: state of the art.Journal of thoracic disease · 2020Review
- A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer.Physics and imaging in radiation oncology · 2020Article
- Volumetric modulated arc therapy versus intensity-modulated proton therapy in neoadjuvant irradiation of locally advanced oesophageal cancer.Radiation oncology (London, England) · 2020Article
- The emerging role of proton therapy for esophagus cancer.Journal of gastrointestinal oncology · 2020Review
- A brief overview of the use of proton beam radiotherapy for gastrointestinal cancers.Journal of gastrointestinal oncology · 2020Article
- Failure patterns after adjuvant chemoradiotherapy following endoscopic resection for superficial esophageal squamous cell carcinoma.Cancer medicine · 2019Article
- Proton beam therapy for cancer in the era of precision medicine.Journal of hematology & oncology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntensity-modulated proton therapy (IMPT) is an emerging advanced radiation technique. Although dosimetric studies demonstrate the superiority of IMPT for improving target conformity and reducing unnecessary dose to critical normal tissues, clinical experience is limited. We aim to describe our preliminary experience implementing IMPT concurrently with chemotherapy in esophageal carcinoma (EC). METHODS AND MATERIALS: From May 2011 through February 2016, 19 patients with EC (median age, 73 years) were treated with IMPT using 180 to 250 MV protons with a median dose of 50.4 Gy relative biological effectiveness in 28 fractions concurrently with chemotherapy. Beam arrangement was most commonly in the posteroanterior and bilateral posterior oblique beams. The Kaplan-Meier method was used to assess survival outcomes. Treatment-related toxicities were evaluated using the Common Terminology Criteria for Adverse Events, version 4.0.
resultsSingle-field and multifield optimization was performed in 13 and 6 patients, respectively. The average gross tumor volume was 69.1 cm
conclusionsIMPT is an effective treatment for EC, with high tumor response, good local control, and acceptable acute toxicity.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.