ArticleFrontiers in physiology2017
Non-linear Heart Rate and Blood Pressure Interaction in Response to Lower-Body Negative Pressure.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Compensatory hemodynamic changes in response to central hypovolemia in humans: lower body negative pressure: updates and perspectives.Journal of muscle research and cell motility · 2023Review
- Mechanical deconditioning of the heart due to long-term bed rest as observed on seismocardiogram morphology.NPJ microgravity · 2022Article
- Canadian aging and inactivity study: Spaceflight-inspired exercises during head-down tilt bedrest blunted reductions in muscle-pump but not cardiac baroreflex in older persons.Frontiers in physiology · 2022Article
- Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization.Scientific reports · 2020Article
- Effect of Aging on Muscle-Pump Baroreflex of Individual Leg Muscles During Standing.Frontiers in physiology · 2019Article
- Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early detection of hemorrhage remains an open problem. In this regard, blood pressure has been an ineffective measure of blood loss due to numerous compensatory mechanisms sustaining arterial blood pressure homeostasis. Here, we investigate the feasibility of causality detection in the heart rate and blood pressure interaction, a closed-loop control system, for early detection of hemorrhage. The hemorrhage was simulated via graded lower-body negative pressure (LBNP) from 0 to -40 mmHg. The research hypothesis was that a significant elevation of causal control in the direction of blood pressure to heart rate (i.e., baroreflex response) is an early indicator of central hypovolemia. Five minutes of continuous blood pressure and electrocardiogram (ECG) signals were acquired simultaneously from young, healthy participants (27 ± 1 years,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.