ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Working Memory and Decision-Making in a Frontoparietal Circuit Model.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 2 of them syntheses that pooled it.
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Who cites it
106 citing papers in PubMed, 2 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Neural correlates of Sudoku play: a systematic review of brain imaging studies.Frontiers in neuroimaging · 2026Pooled it
- Neural correlates of harm avoidance: a multimodal meta-analysis of brain structural and resting-state functional neuroimaging studies.Translational psychiatry · 2024Pooled it
- Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval.Nature communications · 2026Article
- A neurocognitive interactive activation model of semantic priming in lexical decisions.Scientific reports · 2026Article
- Mental cost of simple(st) physical exertion.Cognition · 2026Article
- Dysfunctional oscillatory bursting patterns linked to working memory in adolescents with attention deficit hyperactivity disorder.Cognitive, affective & behavioral neuroscience · 2026Article
- Multiplexed changes in synaptic transmission underlie stress-induced reduction of persistent firing in the parietal cortex.Progress in neurobiology · 2026Article
- A novel framework for expanding RNNs with biophysical detail to solve cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Selective control of prefrontal neural timescales by parietal cortex.Nature communications · 2026Article
- Beyond Working Memory Capacity: Attention Control as the Underlying Mechanism of Cognitive Abilities.Journal of Intelligence · 2026Review
- The Association between Oscillatory Burst Features and Human Working Memory Accuracy.Journal of cognitive neuroscience · 2026Article
- From comparative connectomics to large-scale working memory modeling in macaque and marmoset.Cell reports · 2026Article
- Task demand modulates somatosensory-frontoparietal networks during delay and retrieval periods in tactile working memory.Communications biology · 2026Article
- Computational learning phenotypes are not related to individual differences in resting-state fMRI connectivity.Frontiers in neuroscience · 2026Article
- Bias in Visual Short-Term Memory for Motion Induced by Perceptually Suppressed Distractors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Two-Hit Model of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed by Sleep Fragmentation.Life (Basel, Switzerland) · 2025Article
- Dissociable cortical contributions to impulse control during waiting.Science advances · 2025Article
- Diverse and flexible behavioral strategies arise in recurrent neural networks trained on multisensory decision making.PLoS computational biology · 2025Article
- Bifurcation in space: Emergence of functional modularity in the neocortex.bioRxiv : the preprint server for biology · 2025Article
- From comparative connectomics to large-scale working memory modeling in macaque and marmoset.bioRxiv : the preprint server for biology · 2025Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Working memory (WM) and decision-making (DM) are fundamental cognitive functions involving a distributed interacting network of brain areas, with the posterior parietal cortex (PPC) and prefrontal cortex (PFC) at the core. However, the shared and distinct roles of these areas and the nature of their coordination in cognitive function remain poorly understood. Biophysically based computational models of cortical circuits have provided insights into the mechanisms supporting these functions, yet they have primarily focused on the local microcircuit level, raising questions about the principles for distributed cognitive computation in multiregional networks. To examine these issues, we developed a distributed circuit model of two reciprocally interacting modules representing PPC and PFC circuits. The circuit architecture includes hierarchical differences in local recurrent structure and implements reciprocal long-range projections. This parsimonious model captures a range of behavioral and neuronal features of frontoparietal circuits across multiple WM and DM paradigms. In the context of WM, both areas exhibit persistent activity, but, in response to intervening distractors, PPC transiently encodes distractors while PFC filters distractors and supports WM robustness. With regard to DM, the PPC module generates graded representations of accumulated evidence supporting target selection, while the PFC module generates more categorical responses related to action or choice. These findings suggest computational principles for distributed, hierarchical processing in cortex during cognitive function and provide a framework for extension to multiregional models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.