ArticleThe Journal of experimental medicine2017
Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Bcl-2-Dependent Persistence of Mononuclear Phagocytes Promotes Ocular Fibrosis.International journal of molecular sciences · 2026Article
- Comprehensive analysis of myeloid reporter mice.bioRxiv : the preprint server for biology · 2025Article
- Defective Lamtor5 Leads to Autoimmunity by Deregulating v-ATPase and Lysosomal Acidification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis.Signal transduction and targeted therapy · 2024Article
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell death and differentiation · 2023Review
- The SYSCID map: a graphical and computational resource of molecular mechanisms across rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease.Frontiers in immunology · 2023Article
- Bim Expression Promotes the Clearance of Mononuclear Phagocytes during Choroidal Neovascularization, Mitigating Scar Formation in Mice.Life (Basel, Switzerland) · 2022Article
- High iodine promotes autoimmune thyroid disease by activating hexokinase 3 and inducing polarization of macrophages towards M1.Frontiers in immunology · 2022Article
- Article
- Impaired B Cell Apoptosis Results in Autoimmunity That Is Alleviated by Ablation of Btk.Frontiers in immunology · 2021Article
- MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation.Scientific reports · 2020Article
- Selective nanoparticle-mediated targeting of renal tubular Toll-like receptor 9 attenuates ischemic acute kidney injury.Kidney international · 2020Article
- Multi-state design of flexible proteins predicts sequences optimal for conformational change.PLoS computational biology · 2020Article
- A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus.Frontiers in immunology · 2020Article
- Article
- The anti-tumor growth effect of a novel agent DMAMCL in rhabdomyosarcoma in vitro and in vivo.Journal of experimental & clinical cancer research : CR · 2019Article
- Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus.Frontiers in immunology · 2019Article
- Kidney Proximal Tubular TLR9 Exacerbates Ischemic Acute Kidney Injury.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 2 countries.
FuNien TsaiDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Philip J HomanDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID http://orcid.org/0000-0002-3389-4931
Hemant AgrawalTTP Labtech India Private Limited, Faridabad, India.
Alexander V MisharinDivision of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID http://orcid.org/0000-0003-2879-3789
Hiam Abdala-ValenciaDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
G Kenneth HainesDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY.
Salina DominguezDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Christina L BloomfieldDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID http://orcid.org/0000-0002-6012-3745
Rana SaberDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Anthony ChangDepartment of Pathology, University of Chicago, Chicago, IL.ORCID http://orcid.org/0000-0002-6877-5510
Chandra MohanDepartment of Biomedical Engineering, University of Houston, Houston, TX.
Jack HutchesonTri-Service Research Laboratory, San Antonio, TX.
Anne DavidsonThe Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, Manhasset, NY.ORCID http://orcid.org/0000-0002-4081-6464
G R Scott BudingerDivision of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Philippe BouilletThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Andrea DorfleutnerDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Christian StehlikDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Deborah R WinterDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Carla M CudaDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL c-cuda@northwestern.edu.
Harris PerlmanDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL h-perlman@northwestern.edu.ORCID http://orcid.org/0000-0003-4174-608X
Northwestern University · USFeinstein Institute for Medical Research · USIcahn School of Medicine at Mount Sinai · USUniversity of Chicago · USUniversity of Houston · USWalter and Eliza Hall Institute of Medical Research · AU
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MSmall Animal Surgery and HistologyP01HL108795 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LOSORDO, DOUGLAS W · 2011 to 2015
$10.7MRegulation of cytosolic pattern recognition receptor signaling in macrophagesR01AI099009 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STEHLIK, CHRISTIAN · 2013 to 2022
$4.7MPOSTDOCTORAL RHEUMATOLOGY TRAININGT32AR007611 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2001 to 2022
$4.4MTherapeutic Role for P21 in Suppressing IL-1 Beta Mediated PathologiesR01AR050250 · NIAMS · SAINT LOUIS UNIVERSITY · PI PERLMAN, HARRIS R · 2003 to 2014
$3.0MRole of BH3-Domain Proteins in the Effector Phase of RAR01AR054796 · NIAMS · SAINT LOUIS UNIVERSITY · PI PERLMAN, HARRIS R · 2008 to 2012
$1.8MDevelopment of a Novel RA/Atherosclerosis Mouse ModelR01AR064546 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2013 to 2017
$1.6MCaspase 8: A Novel Suppressor of Dendritic Cell-Mediated AutoimmunityK01AR064313 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CUDA, CARLA M · 2013 to 2017
$597kFACSAria SORP Cell SorterS10OD011996 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOOLSBY, CHARLES L. · 2012 to 2012
$482kInflammasome Adaptor and Effectors in Cryopyrinopathies and Crystal ArthropathiesK01AR066739 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DORFLEUTNER, ANDREA · 2015 to 2019
$471kNCATS NIH HHS UL1 TR001422NCI NIH HHS P30 CA060553NHLBI NIH HHS P01 HL108795NIAID NIH HHS R01 AI099009NIAID NIH HHS R21 AI092490NIAMS NIH HHS K01 AR064313NIAMS NIH HHS K01 AR066739NIAMS NIH HHS R01 AR050250NIAMS NIH HHS R01 AR054796NIAMS NIH HHS R01 AR064546NIAMS NIH HHS T32 AR007611NIA NIH HHS P01 AG049665NIH HHS S10 OD011996
Abstract
The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway. We demonstrate that Bim acts as a molecular rheostat by controlling macrophage function not only in lymphoid organs but also in end organs, thereby preventing the break in tolerance. Mice lacking Bim in myeloid cells (LysM
Indexed as
Adaptor Proteins, Vesicular TransportAdoptive TransferAnimalsAutoimmunityBcl-2-Like Protein 11Cell SurvivalGene DeletionGene Expression ProfilingGlomerulonephritisHumansInflammationKidneyLupus Erythematosus, SystemicMacrophagesMice, Inbred C57BLMice, TransgenicAdaptor Proteins, Vesicular TransportBcl-2-Like Protein 11Myeloid Differentiation Factor 88Ticam1 protein, mouse
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LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.