ArticleProceedings of the National Academy of Sciences of the United States of America2017
Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Competing chemical gradients change chemotactic dynamics and cell distribution.Physical review. E · 2026Article
- Galvanotactic directionality of cell groups depends on group size.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chip collection of hepatocellular carcinoma based on ONature communications · 2024Article
- OScience advances · 2023Article
- Collective chemotaxis in a Voronoi model for confluent clusters.Biophysical journal · 2022Article
- The role of cell geometry and cell-cell communication in gradient sensing.PLoS computational biology · 2022Article
- Collective behaviours in organoids.Current opinion in cell biology · 2021Review
- Roles of leader and follower cells in collective cell migration.Molecular biology of the cell · 2021Review
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- Born to Run? Diverse Modes of Epithelial Migration.Frontiers in cell and developmental biology · 2021Review
- Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Tissue rheology in embryonic organization.The EMBO journal · 2019Review
- Minimal Network Topologies for Signal Processing during Collective Cell Chemotaxis.Biophysical journal · 2018Article
- Collective gradient sensing and chemotaxis: modeling and recent developments.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
When a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to gradients, however, there is a critical difference: Even genetically identical cells have differing responses to chemical signals. With theory and simulation, we show collective chemotaxis is limited by cell-to-cell variation in signaling. We find that when different cells cooperate, the resulting bias can be much larger than the effects of ligand-receptor binding. Specifically, when a strongly responding cell is at one end of a cell cluster, cluster motion is biased toward that cell. These errors are mitigated if clusters average measurements over times long enough for cells to rearrange. In consequence, fluid clusters are better able to sense gradients: We derive a link between cluster accuracy, cell-to-cell variation, and the cluster rheology. Because of this connection, increasing the noisiness of individual cell motion can actually increase the collective accuracy of a cluster by improving fluidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.