Evidence map›Paper›PMID 29114040›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.

Bing Guo, Qing Lyu, Orazio J Slivano, Ronald Dirkx, Christine K Christie, Jan Czyzyk, Aram F Hezel, Ali G Gharavi, Eric M Small, Joseph M Miano

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. MRTF: Basic Biology and Role in Kidney Disease.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Murine Epsins Play an Integral Role in Podocyte Function.Journal of the American Society of Nephrology : JASN · 2020
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Bing GuoAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Qing LyuAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Orazio J SlivanoAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Ronald DirkxAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Christine K ChristieAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Jan CzyzykDepartment of Pathology and Laboratory Medicine and.
Aram F HezelJames P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York; and.
Ali G GharaviDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
Eric M SmallAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Joseph M MianoAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York; j.m.miano@rochester.edu.
University of Rochester · USColumbia University · USHuazhong University of Science and Technology · CN

Funding

Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL132574 · NHLBI · NEW YORK MEDICAL COLLEGE · PI GUPTE, SACHIN A, MIANO, JOSEPH M · 2017 to 2020
$2.5M
Dysregulation of common metabolic and transcriptional pathways in heart and lung fibrosisR01HL133761 · NHLBI · UNIVERSITY OF ROCHESTER · PI SMALL, ERIC M, WOELLER, COLLYNN FREMONT · 2016 to 2019
$2.1M
Regulation and Function of AKAP12A in the Vessel WallR01HL112793 · NHLBI · UNIVERSITY OF ROCHESTER · PI FISHER, EDWARD A, MIANO, JOSEPH M · 2013 to 2016
$2.0M
Regulation of epicardial cell differentiation during development and diseaseR01HL120919 · NHLBI · UNIVERSITY OF ROCHESTER · PI SMALL, ERIC M · 2014 to 2018
$1.9M
Regulation and Function of Myocardin in Vascular PathobiologyR01HL117907 · NHLBI · UNIVERSITY OF ROCHESTER · PI MIANO, JOSEPH M · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL112793NHLBI NIH HHS R01 HL117907NHLBI NIH HHS R01 HL120919NHLBI NIH HHS R01 HL132574NHLBI NIH HHS R01 HL133761
6 · The paper itself

Abstract

Podocytes contain an intricate actin cytoskeleton that is essential for the specialized function of this cell type in renal filtration. Serum response factor (SRF) is a master transcription factor for the actin cytoskeleton, but the

Indexed as

ActininActinsAnimalsCytoskeletonDilatation, PathologicFemaleHumansKidney Tubules, DistalKidney Tubules, ProximalMaleMiceMice, KnockoutPodocytesReceptor, Fibroblast Growth Factor, Type 1Repressor ProteinsRNA, MessengerActa2 protein, mouseActininActinsActn4 protein, mouseFgfr1 protein, mouseMrtfa protein, mousemyocardin-related transcription factor B, mouseReceptor, Fibroblast Growth Factor, Type 1Repressor ProteinsRNA, MessengerSerum Response FactorSRF protein, humanSrf protein, mouseTrans-ActivatorsTranscription FactorsWT1 protein, mouseWT1 Proteinsglomerulopathyknockoutpodocyterenal failureserum response factor

Identifiers

PMID29114040
PMCPMC5791050
OpenAlexW2767589324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.