ArticleScience signaling2017
Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice.
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Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
9.7field-weighted citation impact, top 2% of its field
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Who cites it
59 citing papers in PubMed, 99 citations in OpenAlex.
- Targeting autophagy for postsynaptic organization and cognitive rescue in Fragile X syndrome.Neural regeneration research · 2026Article
- Impaired Activity-Regulated Proteostasis: A Shared Mechanism in Neurodevelopmental Disorders.Biological psychiatry · 2026Review
- Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice.Molecular psychiatry · 2026Article
- Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons.Life science alliance · 2026Article
- Article
- Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.Molecular psychiatry · 2026Article
- Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.Molecular psychiatry · 2026Article
- CYFIP1 governs the development of cortical axons by modulating calcium availability.Nature communications · 2025Article
- A rapid and dynamic role for FMRP in the plasticity of adult neurons.Nature communications · 2025Article
- Cell Type-Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory.Journal of neurochemistry · 2025Review
- Extracellular Vesicles-Dependent Secretion Regulates Intracellular CYFIP2 Protein Homeostasis in Cortical Neurons.Biomedicines · 2025Article
- Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors.Journal of medicinal chemistry · 2025Article
- Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.Research square · 2025Article
- FMRP drives mRNP targets into translationally silenced complexes.Molecular cell · 2025Article
- Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators.Science advances · 2025Article
- Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.Journal of medicinal chemistry · 2025Article
- Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.Journal of medicinal chemistry · 2025Article
- The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation.Science advances · 2024Article
- Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.Biological psychiatry · 2024Article
- mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS.EMBO molecular medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 4 countries.
Emanuela SantiniCenter for Neural Science, New York University, New York, NY 10003, USA.ORCID http://orcid.org/0000-0002-8948-9652
Thu N HuynhCenter for Neural Science, New York University, New York, NY 10003, USA.ORCID http://orcid.org/0000-0002-7625-5101
Francesco LongoCenter for Neural Science, New York University, New York, NY 10003, USA.ORCID http://orcid.org/0000-0002-1183-0101
So Yeon KooCenter for Neural Science, New York University, New York, NY 10003, USA.ORCID http://orcid.org/0000-0001-8634-7643
Edward MojicaCenter for Neural Science, New York University, New York, NY 10003, USA.ORCID http://orcid.org/0000-0002-6054-3096
Laura D'AndreaDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata," 00133 Rome, Italy.
Claudia BagniDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata," 00133 Rome, Italy.
Eric KlannCenter for Neural Science, New York University, New York, NY 10003, USA. eklann@cns.nyu.edu.ORCID http://orcid.org/0000-0001-7379-6802
New York University · USUniversity of Rome Tor Vergata · IT
Funding
Strategies to rescue PI3K dysregulation in Fragile X SyndromeU54HD082013 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RICHTER, JOEL D · 2014 to 2019
$10.2MTranslation Regulation in Hippocampal LTP and LTDR01NS047384 · NINDS · NEW YORK UNIVERSITY · PI KLANN, ERIC · 2005 to 2020
$5.2MReactive Oxygen Species Signaling in the HippocampusR01NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 2000 to 2012
$4.2MeIF2alpha Phosphorylation in Synaptic Plasticity, Memory, and Brain DisordersR37NS034007 · NINDS · NEW YORK UNIVERSITY · PI KLANN, ERIC · 2014 to 2020
$3.3MSTRIATAL SPECIFIC ALTERATIONS IN TRANSLATION, SYNAPTIC FUNCTION, AND BEHAVIOR INR00NS087112 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTINI, EMANUELA · 2017 to 2018
$498kStriatal Specific Alterations in Translation, Synaptic Function, and Behavior inK99NS087112 · NINDS · NEW YORK UNIVERSITY · PI SANTINI, EMANUELA · 2014 to 2015
$163kOXIDATIVE ACTIVATION OF PKC DURING INDUCTION OF LTPR29NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 1995 to 1999
–NICHD NIH HHS U54 HD082013NINDS NIH HHS K99 NS087112NINDS NIH HHS R00 NS087112NINDS NIH HHS R01 NS034007NINDS NIH HHS R01 NS047384NINDS NIH HHS R29 NS034007NINDS NIH HHS R37 NS034007
Abstract
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and autism spectrum disorder. FXS is caused by silencing of the
Indexed as
ActinsAdaptor Proteins, Signal TransducingAnimalsDendritic SpinesDisease Models, AnimalEukaryotic Initiation Factor-4EEukaryotic Initiation Factor-4GFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHippocampusHydrazonesMaleMemory DisordersMiceMice, Inbred C57BLNerve Tissue Proteins4EGI-1 compoundActinsAdaptor Proteins, Signal TransducingCyfip1 protein, mouseeIF4E protein, mouseEukaryotic Initiation Factor-4EEukaryotic Initiation Factor-4GFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1HydrazonesNerve Tissue ProteinsThiazoles
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.