Evidence map›Paper›PMID 29114027›Full record

ArticlemBio2017

An

Emily A Byrd, Margaret Kielian

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Chemical reviews · 2026
    Review
  2. Article
  3. Entry receptors - the gateway to alphavirus infection.The Journal of clinical investigation · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emily A ByrdDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Margaret KielianDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA margaret.kielian@einstein.yu.edu.ORCID 0000-0002-7395-4791
Albert Einstein College of Medicine · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Molecular Analysis of Alphavirus Membrane Fusion ProteinR01AI075647 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KIELIAN, MARGARET · 2007 to 2023
$9.0M
NCI NIH HHS P30 CA013330NIAID NIH HHS R01 AI075647NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

Alphaviruses are members of a group of small enveloped RNA viruses that includes important human pathogens such as Chikungunya virus and the equine encephalitis viruses. The virus membrane is covered by a lattice composed of 80 spikes, each a trimer of heterodimers of the E2 and E1 transmembrane proteins. During virus endocytic entry, the E1 glycoprotein mediates the low-pH-dependent fusion of the virus membrane with the endosome membrane, thus initiating virus infection. While much is known about E1 structural rearrangements during membrane fusion, it is unclear how the E1/E2 dimer dissociates, a step required for the fusion reaction. A recent

Indexed as

Virus ReleaseAnimalsCell LineCricetinaeHistidineMembrane FusionMembrane GlycoproteinsModels, MolecularMutationNucleocapsidProtein ConformationProtein MultimerizationSemliki forest virusViral Envelope ProteinsVirus AssemblyVirus InternalizationE1 glycoprotein, Semliki forest virusHistidineMembrane GlycoproteinsViral Envelope Proteinsalphavirusvirus assemblyvirus buddingvirus entryvirus fusionvirus structure

Identifiers

PMID29114027
PMCPMC5676042
OpenAlexW2768043460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.