Evidence map›Paper›PMID 29114017›Full record

ArticleRNA (New York, N.Y.)2018

A microRNA feedback loop regulates global microRNA abundance during aging.

Sachi Inukai, Zachary Pincus, Alexandre de Lencastre, Frank J Slack

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. New Roles for MicroRNAs in Old Worms.Frontiers in aging · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Ageing,The Malaysian journal of medical sciences : MJMS · 2020
    Review
  19. Article
  20. Stimulation ofFrontiers in immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sachi InukaiDepartment of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, Connecticut 06520, USA.
Zachary PincusDepartment of Developmental Biology.
Alexandre de LencastreDepartment of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, Connecticut 06520, USA.
Frank J SlackDepartment of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, Connecticut 06520, USA.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
MicroRNAs in agingR01AG033921 · NIA · YALE UNIVERSITY · PI SLACK, FRANK J. · 2009 to 2018
$3.3M
Discover determinants of individual longevity and health in C. elegansR00AG042487 · NIA · WASHINGTON UNIVERSITY · PI PINCUS, ZACHARY · 2014 to 2016
$740k
Molecular Mechanisms of miRNA Function in Stress Response and in Models of Diseases of Aging in C. elegansR15AG051132 · NIA · QUINNIPIAC UNIVERSITY · PI DE LENCASTRE, ALEXANDRE · 2015 to 2015
$278k
Discover determinants of individual longevity and health in C. elegansK99AG042487 · NIA · YALE UNIVERSITY · PI PINCUS, ZACHARY · 2012 to 2013
$141k
NCATS NIH HHS UL1 TR001102NIA NIH HHS K99 AG042487NIA NIH HHS R00 AG042487NIA NIH HHS R01 AG033921NIA NIH HHS R15 AG051132NIH HHS P40 OD010440
6 · The paper itself

Abstract

Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated the network of genes that controls miRNA transcription and processing during

Indexed as

Gene Expression RegulationAgingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsFeedback, PhysiologicalGene Regulatory NetworksLongevityMicroRNAsRNA-Binding ProteinsALG-1 protein, C elegansCaenorhabditis elegans ProteinsMicroRNAsMIRN71 microRNA, C elegansRNA-Binding ProteinsagingArgonauteCaenorhabditis elegansmicroRNAsmiR-71

Identifiers

PMID29114017
PMCPMC5769744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.