Evidence map›Paper›PMID 29113982›Full record

ArticleGenome research2017

Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair.

Ryan J McGinty, Rachel G Rubinstein, Alexander J Neil, Margaret Dominska, Denis Kiktev, Thomas D Petes, Sergei M Mirkin

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Creation and resolution of non-B-DNA structural impediments during replication.Critical reviews in biochemistry and molecular biology · 2022
    Article
  7. Diagnostic capabilities of nanopore long-read sequencing in muscular dystrophy.Annals of clinical and translational neurology · 2022
    Article
  8. Article
  9. Article
  10. Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Review
  12. Article
  13. Genome-Wide Analysis of Mitotic Recombination in Budding Yeast.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Oxford Nanopore MinION Sequencing Enables Rapid Whole Genome Assembly ofThe American journal of tropical medicine and hygiene · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ryan J McGintyDepartment of Biology, Tufts University, Medford, Massachusetts 02155, USA.
Rachel G RubinsteinDepartment of Biology, Tufts University, Medford, Massachusetts 02155, USA.
Alexander J NeilDepartment of Biology, Tufts University, Medford, Massachusetts 02155, USA.
Margaret DominskaDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Denis KiktevDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Thomas D PetesDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Sergei M MirkinDepartment of Biology, Tufts University, Medford, Massachusetts 02155, USA.
Tufts University · USDuke University · US

Funding

Mutations Arising During DNA RepairP01GM105473 · NIGMS · BRANDEIS UNIVERSITY · PI HABER, JAMES E · 2014 to 2018
$8.6M
Genetic regulation of genome stability in yeastR35GM118020 · NIGMS · DUKE UNIVERSITY · PI PETES, THOMAS · 2016 to 2025
$7.0M
REPLICATION OF SIMPLE DNA REPEATSR01GM060987 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MIRKIN, SERGEI · 2001 to 2017
$4.9M
NIGMS NIH HHS P01 GM105473NIGMS NIH HHS R01 GM060987NIGMS NIH HHS R35 GM118020
6 · The paper itself

Abstract

Improper DNA double-strand break (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congenital disorders in humans. Trinucleotide repeat sequences, such as (GAA)

Indexed as

DNA Breaks, Double-StrandedDNA, FungalDNA RepairGene RearrangementNanoporesChromosomes, FungalGene DuplicationGenome, FungalRetroelementsSaccharomyces cerevisiaeSequence Analysis, DNATrinucleotide RepeatsDNA, FungalRetroelements

Identifiers

PMID29113982
PMCPMC5741057
OpenAlexW2767383011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.