ArticleEMBO molecular medicine2018
G-quadruplex-binding small molecules ameliorate
Open access · goldAbstract read
In one paragraph
Article in EMBO molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.
- RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges.Pharmacological reviews · 2020Pooled it
- Short Tandem Repeat 3D Structure Database (STR3SD): A Resource for Structural Biology Research of Short Tandem Repeats in Neurodegenerative Disorders.International journal of molecular sciences · 2026Review
- Noncoding RNAs are indispensable architects and regulators of biomolecular condensates.Non-coding RNA research · 2026Review
- Effects of Loop Nucleobase Substitution on G-Quadruplex Thermal Stability in Aqueous Glycine Betaine, Proline, TMAO, and Urea Solutions.Biomolecules · 2026Article
- Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.Nucleic acids research · 2026Article
- Role of mitochondria in neuronal function and survival in the enteric and central nervous systems.Cellular and molecular life sciences : CMLS · 2026Review
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- RNA-Focused DNA-Encoded Library Construction, Screening, and Integration of Docking Identify Bioactive Ligands of Pathogenic r(GbioRxiv : the preprint server for biology · 2025Article
- Aryl Guanyl Hydrazones: A Viable Strategy for Designing BBB-Permeable, Neuroactive Compounds?ACS chemical neuroscience · 2025Review
- Therapeutic Approaches for C9ORF72-Related ALS: Current Strategies and Future Horizons.International journal of molecular sciences · 2025Review
- Unraveling the Molecular Basis for G-Quadruplex-Binders to ALS/FTD-Associated G4C2 Repeats of the C9orf72 Gene.Chembiochem : a European journal of chemical biology · 2025Article
- High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.Nucleic acids research · 2025Article
- Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence.ACS chemical biology · 2025Article
- Generation ofbioRxiv : the preprint server for biology · 2025Article
- A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD.Nature communications · 2025Article
- Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo.Nature communications · 2025Article
- Therapeutic targeting of RNA for neurological and neuromuscular disease.Genes & development · 2024Review
- Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids.Acta neuropathologica communications · 2024Article
- RNA G-quadruplexes and stress: emerging mechanisms and functions.Trends in cell biology · 2024Review
- Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression.Cancer discovery · 2024Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors at 6 institutions in 5 countries.
Roberto SimoneDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Rubika BalendraDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Thomas G MoensDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Elisavet PrezaDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Katherine M WilsonDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Amanda HeslegraveDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Nathan S WoodlingDepartment of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
Teresa NiccoliDepartment of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
Javier Gilbert-JaramilloDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Samir AbdelkarimMRC Centre for Neuromuscular Disease UCL Institute of Neurology, London, UK.
Emma L ClaytonDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Mica ClarkeDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Marie-Therese KonradDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Andrew J NicollDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Jamie S MitchellDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Andrea Calvo'Rita Levi Montalcini' Department of Neuroscience, ALS Centre University of Turin, Turin, Italy.
Adriano Chio'Rita Levi Montalcini' Department of Neuroscience, ALS Centre University of Turin, Turin, Italy.
Henry HouldenDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
James M PolkeNeurogenetics Unit UCL Institute of Neurology, London, UK.
Mohamed A IsmailDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.
Chad E StephensDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.
Tam VoDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.
Abdelbasset A FarahatDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.
W David WilsonDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.
David W BoykinDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.
Henrik ZetterbergDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Linda PartridgeDepartment of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.ORCID 0000-0001-9615-0094
Selina WrayDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Gary ParkinsonUCL School of Pharmacy, London, UK.
Stephen NeidleUCL School of Pharmacy, London, UK s.neidle@ucl.ac.uk rickie.patani@ucl.ac.uk p.fratta@ucl.ac.uk a.isaacs@ucl.ac.uk.ORCID 0000-0003-0622-6548
Rickie PataniDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK s.neidle@ucl.ac.uk rickie.patani@ucl.ac.uk p.fratta@ucl.ac.uk a.isaacs@ucl.ac.uk.ORCID 0000-0002-3825-7675
Pietro FrattaMRC Centre for Neuromuscular Disease UCL Institute of Neurology, London, UK s.neidle@ucl.ac.uk rickie.patani@ucl.ac.uk p.fratta@ucl.ac.uk a.isaacs@ucl.ac.uk.ORCID 0000-0002-8762-8188
Adrian M IsaacsDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK s.neidle@ucl.ac.uk rickie.patani@ucl.ac.uk p.fratta@ucl.ac.uk a.isaacs@ucl.ac.uk.ORCID 0000-0002-6820-5534
University College London · GBGeorgia State University · USMRC Prion Unit · GBUK Dementia Research Institute · GBUniversity of Turin · ITMax Planck Institute for Biology of Ageing · DE
Funding
Molecular Design for Specific Recognition of Functional DNA SequencesR01GM111749 · NIGMS · GEORGIA STATE UNIVERSITY · PI WILSON, W DAVID · 2014 to 2021
$2.5MDepartment of HealthMedical Research Council MR/M008606/1Motor Neurone Disease Association FRATTA/JAN15/946-795Motor Neurone Disease Association ISAACS/APR13/818-791NIGMS NIH HHS R01 GM111749Wellcome TrustWellcome Trust 101149/Z/13/AWellcome Trust 107196/Z/14/Z
Abstract
Intronic GGGGCC repeat expansions in
Indexed as
Drug DiscoveryAmyotrophic Lateral SclerosisAnimalsC9orf72 ProteinDrosophilaFrontotemporal DementiaG-QuadruplexesHumansRepetitive Sequences, Nucleic AcidRNASmall Molecule LibrariesC9orf72 ProteinRNASmall Molecule Librariesamyotrophic lateral sclerosisC9orf72frontotemporal dementiaG‐quadruplex
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.