ArticleParasitology2018
Dermotropic Leishmania donovani in Sri Lanka: visceralizing potential in clinical and preclinical studies.
Article in Parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Isolation and characterisation of Leishmania (Leishmania) infantum from cutaneous leishmaniasis patients in northeast Brazil.Memorias do Instituto Oswaldo Cruz · 2024Article
- Diagnostic Tools for Cutaneous Leishmaniasis Caused byDiagnostics (Basel, Switzerland) · 2023Review
- From Infection to Death: An Overview of the Pathogenesis of Visceral Leishmaniasis.Pathogens (Basel, Switzerland) · 2023Review
- Cytokine and phenotypic cell profiles in human cutaneous leishmaniasis caused by Leishmania donovani.PloS one · 2023Article
- Assessment of Risk of Exposure toPathogens (Basel, Switzerland) · 2022Article
- Experimental Hybridization inPathogens (Basel, Switzerland) · 2022Review
- Stress conditions promoteeLife · 2022Article
- Mechanisms of Immunopathogenesis in Cutaneous Leishmaniasis And Post Kala-azar Dermal Leishmaniasis (PKDL).Frontiers in cellular and infection microbiology · 2021Review
- Detection ofJournal of tropical medicine · 2021Article
- Treatment failure to sodium stibogluconate in cutaneous leishmaniasis: A challenge to infection control and disease elimination.PloS one · 2021Article
- A Comprehensive Review of Cutaneous Leishmaniasis in Sri Lanka and Identification of Existing Knowledge Gaps.Acta parasitologica · 2020Review
- Spatial Epidemiologic Trends and Hotspots of Leishmaniasis, Sri Lanka, 2001-2018.Emerging infectious diseases · 2020Article
- Article
- Trends in Recently EmergedBioMed research international · 2019Article
- Evaluation of rapid extraction and isothermal amplification techniques for the detection of Leishmania donovani DNA from skin lesions of suspected cases at the point of need in Sri Lanka.Parasites & vectors · 2018Article
- Leishmaniasis: current challenges and prospects for elimination with special focus on the South Asian region.Parasitology · 2018Article
- The Economic Impact of Cutaneous Leishmaniasis in Sri Lanka.BioMed research international · 2018Article
- Evidence for Seroprevalence in Human Localized Cutaneous Leishmaniasis Caused byBioMed research international · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka (L. donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) patients and in vivo and in vitro experimental infection models. CL patients (n = 250) treated effectively with intra-lesional antimony therapy were followed-up six monthly for 4 years. There was no clinical evidence of visceralization of infection (VL) during this period. Infection of BALB/c mice with L. donovani-SL (test) through intra-dermal route led to the development of cutaneous lesions at the site of inoculation with no signs of systemic dissemination, in contrast to the observations made in animals similarly infected with a visceralizing strain of L. donovani-1S (control). Cytokine (IL-10, IFN-γ) release patterns of splenocytes and lymph node cell cultures derived from mice primed with experimental infections (with either test or control parasites) revealed significantly high IFN-γ response associated with test mice with CL, while prominent IL-10 levels were observed in association with control mice with VL. Furthermore, diminished infection efficiency, intracellular growth and survival of L. donovani-SL parasites compared with L. donovani-1S were evident through in vitro macrophage infection experiments. These studies confirm, for the first time, the essential dermotropic nature of L. donovani-SL suggesting natural attenuation of virulence of local parasite strains.
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