Evidence map›Paper›PMID 29113429›Full record

ArticleMolecules and cells2017

Endophilin A2: A Potential Link to Adiposity and Beyond.

Assim A Alfadda, Reem M Sallam, Rukhsana Gul, Injae Hwang, Sojeong Ka

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Assim A AlfaddaObesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Reem M SallamObesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Rukhsana GulObesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Injae HwangDepartment of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Korea.
Sojeong KaDepartment of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.
King Saud University · SASeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue plays a central role in regulating dynamic crosstalk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes in adipose tissue mass is expected to increase our understanding of the molecular mechanisms that underlie obesity and related metabolic co-morbidities. Our previous studies suggest a possible link between endophilins (SH3Grb2 proteins) and changes in body weight. To explore this further, we sought to assess the distribution of endophilin A2 (EA2) in human adipose tissue and experimental animals. Human paired adipose tissue samples (subcutaneous and visceral) were collected from subjects undergoing elective abdominal surgery and abdominal liposuction. We observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with TNF-α in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. In conclusion, this study provides a description of EA2 distribution and emphasizes a need to study the roles of this protein during the progression of obesity.

Indexed as

Up-Regulation3T3-L1 CellsAdipocytesAdiponectinAnimalsCell DifferentiationChemokinesHumansIntercellular Signaling Peptides and ProteinsIntra-Abdominal FatIntracellular Signaling Peptides and ProteinsLipectomyMaleMiceMice, Inbred C57BLModels, AnimalAdiponectinADIPOQ protein, humanChemokinesIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsRARRES2 protein, humanSH3GL1 protein, humanTNF protein, humanTumor Necrosis Factor-alphaadipose tissueendophilin A2obesitySH3GL1

Identifiers

PMID29113429
PMCPMC5712515
OpenAlexW2923963659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.