Evidence map›Paper›PMID 29113402›Full record

ArticleOncotarget2017

Patterns of relapse in patients with localized gastric adenocarcinoma who had surgery with or without adjunctive therapy: costs and effectiveness of surveillance.

Elena Elimova, Rebecca S Slack, Hsiang-Chun Chen, Venkatram Planjery, Hironori Shiozaki, Yusuke Shimodaira, Nick Charalampakis, Quan Lin, Kazuto Harada, Roopma Wadhwa and 13 more

Abstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Recent trend in gastric cancer treatment in the USA.Journal of cancer metastasis and treatment · 2018
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Elena ElimovaDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Rebecca S SlackDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Hsiang-Chun ChenDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Venkatram PlanjeryDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Hironori ShiozakiDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Yusuke ShimodairaDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Nick CharalampakisDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Quan LinDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Kazuto HaradaDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Roopma WadhwaDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Jeannelyn S EstrellaDepartment of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Dilsa Mizrak KayaDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Tara SagebielDepartment of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Jeffrey H LeeDepartment of Gastroenterology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Brian WestonDepartment of Gastroenterology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Manoop BhutaniDepartment of Gastroenterology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Mariela Blum MurphyDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Aurelio MatamorosDepartment of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Bruce MinskyDepartment of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Prajnan DasDepartment of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Paul F MansfieldDepartment of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Brian D BadgwellDepartment of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Jaffer A AjaniDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Prediction of Pathologic Complete Response by Gene Expression Profiling in EsophaR01CA138671 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AJANI, JAFFER A. · 2010 to 2014
$1.5M
Inhibition of Hedgehog Signaling in Gli-1+Adeno CA of the Esoph or GE junctionR01CA172741 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AJANI, JAFFER A. · 2013 to 2017
$1.4M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA138671NCI NIH HHS R01 CA172741
6 · The paper itself

Abstract

purposeAfter therapy of localized gastric adenocarcinoma (GAC) patients, the costs of surveillance, relapse patterns, and possibility of salvage are unknown. MATERIALS AND

methodsWe identified 246 patients, who after having a negative peritoneal staging, received therapy (any therapy which included surgery) and were surveyed (every 3-6 months in the first 3 years, then yearly; ∼10 CTs and ∼7 endoscopies per patient). We used the 2016 Medicare dollars reimbursed as the "costs" for surveillance.

resultsCommon features were: Caucasians (57%), men (60%), poorly differentiated histology (76%), preoperative chemotherapy (74%), preoperative chemoradiation (59%), and had surgery (100%). At a median follow-up of 3.7 years (range, 0.1 to 18.3), the median overall survival (OS) was 9.2 years (95% CI, 6.0 to 11.2). Tumor grade (

conclusionsThe median OS of localized GAC patients was excellent with infrequent local-regional relapses. Rigorous surveillance had a low yield and high "costs". Our data suggest that less frequent surveillance intervals and limiting expensive investigations to symptomatic patients may be warranted.

Indexed as

cancer surveillancecost-effectiveness analysisesophagogastroduodenoscopyimaging studieslocalized gastric adenocarcinoma

Identifiers

PMID29113402
PMCPMC5655297

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.