ArticleOncotarget2017
B7-H4 overexpression is essential for early hepatocellular carcinoma progression and recurrence.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Immune checkpoint biology in hepatocellular carcinoma (Review).Oncology letters · 2025Review
- B7H4 Role in Solid Cancers: A Review of the Literature.Cancers · 2024Review
- The stromal tumor-infiltrating lymphocytes, cancer stemness, epithelial-mesenchymal transition, and B7-H4 expression in ovarian serous carcinoma.Journal of ovarian research · 2023Article
- Depletion of B7-H4 from C3H10 T1/2 Mesenchymal Stem Cells Attenuates their Immunomodulatory Therapy in Experimental Autoimmune Encephalomyelitis Mice.Neurotoxicity research · 2022Article
- High membrane expression of CMTM6 in hepatocellular carcinoma is associated with tumor recurrence.Cancer science · 2021Article
- Phenotypic and Functional Analyses of B7S1 in Ovarian Cancer.Frontiers in molecular biosciences · 2021Article
- Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-Journal of oncology · 2020Article
- Prognostic role of immune cells in hepatocellular carcinoma.EXCLI journal · 2020Review
- The B7x Immune Checkpoint Pathway: From Discovery to Clinical Trial.Trends in pharmacological sciences · 2019Review
- Downregulation of B7-H4 suppresses tumor progression of hepatocellular carcinoma.Scientific reports · 2019Article
- Monitoring Immune Checkpoint Regulators as Predictive Biomarkers in Hepatocellular Carcinoma.Frontiers in oncology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B7-H4, another member of costimulatory molecule, has been shown to be overexpressed in multiple types of tumors, including hepatocellular carcinoma (HCC). However, the specific biological role of B7-H4 in HCC still needs to be further explored. In this study, we observed that B7-H4 was highly overexpressed in HCC tissues and cells, and its overexpression strongly correlated with patient's TNM stage, overall survival and early recurrence. Downregulation of B7-H4 significantly suppressed cell growth, invasion, and stemness of HCC by inducing apoptosis in the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.