Evidence map›Paper›PMID 29113293›Full record

ArticleOncotarget2017

Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States.

Moshen Mazidi, Peyman Rezaie, Adriac Covic, Jolanta Malyszko, Jacek Rysz, Andre Pascal Kengne, Maciej Banach

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Genetic association study ofRenal failure · 2024
    Article
  7. Article
  8. Review
  9. Telomere Attrition in Chronic Kidney Diseases.Antioxidants (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Review
  18. Article
  19. Adverse Impact ofNutrients · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Moshen MazidiKey State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Peyman RezaieKey State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Adriac CovicNephrology Clinic, Parhon University Hospital, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania.
Jolanta MalyszkoDepartment of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.
Jacek RyszDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Zeromskiego, Lodz, Poland.
Andre Pascal KengneNon-Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, Cape Town, South Africa.
Maciej BanachDepartment of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.
Chinese Academy of Sciences · CNGrigore T. Popa University of Medicine and Pharmacy · ROInstitute of Genetics and Developmental Biology · CNMedical University of Białystok · PLMedical University of Lodz · PLPolish Mother’s Memorial Hospital Research Institute · PLUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTelomere length is an emerging novel biomarker of biologic age, cardiovascular risk and chronic medical conditions. Few studies have focused on the association between telomere length (TL) and kidney function.

objectiveWe investigated the association between TL and kidney function/prevalent chronic kidney disease (CKD) in US adults.

methodsThe National Health and Nutrition Examination Survey (NHANES) participants with measured data on kidney function and TL from 1999 to 2002 were included. Estimated glomerular filtration rate (eGFR) was based on CKD Epidemiology Collaboration (CKD-EPI) equation. Urinary albumin excretion was assessed using urinary albumin-creatinine ratio (ACR). We used multivariable adjusted linear and logistic regression models, accounting for the survey design and sample weights.

resultsOf the 10568 eligible participants, 48.0% (

conclusionThe association of kidney function with a marker of cellular senescence suggests an underlying mechanism influencing the progression of nephropathy.

Indexed as

albumin-creatinine ratioGerotargetglomerular filtration ratekidney functionnational health and nutrition examination surveytelomere length

Identifiers

PMID29113293
PMCPMC5655188
OpenAlexW2752949471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.