Evidence map›Paper›PMID 29113235›Full record

ArticleOncology letters2017

Dysregulation of KRAS signaling in pancreatic cancer is not associated with

Radmila Lemstrova, Veronika Brynychova, David J Hughes, Viktor Hlavac, Pavel Dvorak, Joanne E Doherty, Helena A Murray, Martin Crockard, Martin Oliverius, Jan Hlavsa and 10 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  5. p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  6. Article
  7. A PET Imaging Strategy for Interrogating Target Engagement and Oncogene Status in Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Radmila LemstrovaDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, 771 47 Olomouc, Czech Republic.
Veronika BrynychovaDepartment of Toxicogenomics, National Institute of Public Health, 100 42 Prague, Czech Republic.
David J HughesDepartment of Physiology and Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Republic of Ireland.
Viktor HlavacDepartment of Toxicogenomics, National Institute of Public Health, 100 42 Prague, Czech Republic.
Pavel DvorakDepartment of Biology, Faculty of Medicine in Pilsen, Charles University 32300 Pilsen, Czech Republic.
Joanne E DohertyRandox Laboratories Ltd., Crumlin, BT29 4QY, Northern Ireland.
Helena A MurrayRandox Laboratories Ltd., Crumlin, BT29 4QY, Northern Ireland.
Martin CrockardRandox Laboratories Ltd., Crumlin, BT29 4QY, Northern Ireland.
Martin OliveriusDepartment of Transplantation Surgery, Institute of Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Jan HlavsaDepartment of Surgery, University Hospital and Medical Faculty, Masaryk University, 625 00 Brno, Czech Republic.
Eva HonsovaDepartment of Clinical and Transplantation Pathology, Institute of Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Jan MazanecDepartment of Pathology, University Hospital and Medical Faculty, Masaryk University, 625 00 Brno, Czech Republic.
Zdenek KalaDepartment of Surgery, University Hospital and Medical Faculty, Masaryk University, 625 00 Brno, Czech Republic.
Martin LovecekDepartment of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, 771 47 Olomouc, Czech Republic.
Roman HavlikDepartment of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, 771 47 Olomouc, Czech Republic.
Jiri EhrmannDepartment of Clinical and Molecular Pathology and Laboratory of Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, 771 47 Olomouc, Czech Republic.
Ondrej StrouhalDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, 771 47 Olomouc, Czech Republic.
Pavel SoucekDepartment of Toxicogenomics, National Institute of Public Health, 100 42 Prague, Czech Republic.
Bohuslav MelicharDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, 771 47 Olomouc, Czech Republic.
Beatrice Mohelnikova-DuchonovaDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, 771 47 Olomouc, Czech Republic.
Palacký University Olomouc · CZMasaryk University · CZNational Institute of Public Health · CZUniversity Hospital Olomouc · CZInstitute of Clinical and Experimental Medicine · CZCharles University · CZRoyal College of Surgeons in Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a tumor with a poor prognosis, and no targeted therapy is currently available. The aim of the present study was to investigate the prognostic significance of the expression of V-Ki-ras2 Κirsten rat sarcoma viral oncogene homolog (

Indexed as

gene expressionKRASmutationoverall survivalpancreatic ductal adenocarcinoma

Identifiers

PMID29113235
PMCPMC5661609
OpenAlexW2756187736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.