Evidence map›Paper›PMID 29112867›Full record

ArticleCurrent biology : CB2017

Mechanosensation: A Catch Bond That Only Hooks One Way.

Vinay Swaminathan, Gregory M Alushin, Clare M Waterman

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. De novo DNA-based catch bonds.Nature chemistry · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Greg Alushin: The shape of things to come.The Journal of cell biology · 2019
    Article
  8. Piezo1 and GThe Journal of experimental medicine · 2018
    Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Vinay SwaminathanCell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Gregory M AlushinLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY 10065, USA.
Clare M WatermanCell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: watermancm@nhlbi.nih.gov.
National Institutes of Health · USRockefeller University · US

Funding

Integration of Actin Dynamics and Adhesion in Cell MigrationZIAHL005105 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WATERMAN, CLARE MICHAL · 2009 to 2025
$16.5M
Integration of Actin Dynamics and Adhesion in Cell MigrationZ01HL005105 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WATERMAN, CLARE MICHAL · 2008 to 2008
$681k
Intramural NIH HHS Z01 HL005105
6 · The paper itself

Abstract

Single-molecule force spectroscopy and modeling have revealed that the adhesion molecule vinculin and F-actin form a catch bond that is dependent on the direction of forces along the actin filament. This may underlie the mechanisms by which cells sense directional physical cues.

Indexed as

Actin CytoskeletonActinsProtein BindingSingle Molecule ImagingVinculinActinsVinculin

Identifiers

PMID29112867
PMCPMC6145086
OpenAlexW2767747752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.