Evidence map›Paper›PMID 29112780›Full record

ArticleClinical endocrinology2018

Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children.

Aino Mäntyselkä, Jarmo Jääskeläinen, Aino-Maija Eloranta, Juuso Väistö, Raimo Voutilainen, Ken Ong, Søren Brage, Timo A Lakka, Virpi Lindi

Abstract read
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In one paragraph

Article in Clinical endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Aino MäntyselkäDepartment of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.ORCID 0000-0001-9537-7668
Jarmo JääskeläinenDepartment of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Aino-Maija ElorantaDepartment of Physiology, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Juuso VäistöDepartment of Physiology, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Raimo VoutilainenDepartment of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Ken OngMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Søren BrageMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Timo A LakkaDepartment of Physiology, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Virpi LindiDepartment of Physiology, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
University of Eastern Finland · FIUniversity of Cambridge · GB

Funding

Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/3
6 · The paper itself

Abstract

objectiveLittle is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEAS and IGF-1 in children. DESIGN AND SUBJECTS: Cross-sectional analysis of a population sample of 431 prepubertal children aged 6-9 years. MEASUREMENTS: Assessment of dietary factors by food records and physical activity and sedentary behaviour by a combined heart rate and movement monitor and a questionnaire. Measurement of serum DHEAS and IGF-1.

resultsConsumption of low-fibre grain products (standardized regression coefficient β = .118, P = .017) and intake of vegetable protein (β = .100, P = .045) was positively and consumption of sugar-sweetened beverages (β = -.117, P = .018) was inversely associated with DHEAS after adjustment for sex, age and body fat percentage. Energy intake (β = .160, P = .001) was positively associated with IGF-1 adjusting for sex, age and body fat percentage. Vigorous physical activity was inversely associated with DHEAS after adjustment for sex and age (β = -.120, P = .027), and total (β = -.137, P = .007), moderate (β = -.130, P = .012), vigorous (β = -.136, P = .011) and moderate to vigorous physical activity (β = -.160, P = .003) were inversely and total sedentary behaviour (β = .151, P = .003) was positively associated with IGF-1 adjusting for sex and age. None of physical activity measures was associated with DHEAS or IGF-1 after additional adjustment for body fat percentage.

conclusionsLifestyle factors have weak and moderate associations with biochemical markers of adrenarche in prepubertal children. These associations indicate body fat independent and dependent influences of diet and physical activity, respectively.

Indexed as

Body CompositionBody SizeChildCross-Sectional StudiesDehydroepiandrosterone SulfateExerciseFemaleHumansInsulin-Like Growth Factor IMaleSedentary BehaviorSurveys and QuestionnairesDehydroepiandrosterone SulfateIGF1 protein, humanInsulin-Like Growth Factor Ibody fat percentagedehydroepiandrosterone sulphateinsulin-like growth factor-1lean body masslifestyle factors

Identifiers

PMID29112780
PMCPMC6195184
OpenAlexW2767600634

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.