Evidence map›Paper›PMID 29112746›Full record

ReviewThe Journal of infectious diseases2017

Tuberculosis Infectiousness and Host Susceptibility.

Richard D Turner, Christopher Chiu, Gavin J Churchyard, Hanif Esmail, David M Lewinsohn, Neel R Gandhi, Kevin P Fennelly

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Article
  3. Genomic epidemiology ofMicrobial genomics · 2026
    Article
  4. Article
  5. Article
  6. Host- and pathogen-related determinants of pulmonaryEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. La Tunisie medicale · 2024
    Review
  17. Article
  18. Article
  19. Duration of Effective Tuberculosis Treatment, not Acid-Fast Bacilli (AFB) Smear Status, as the Determinant for Deisolation in Community Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  20. Pangenome Reconstruction ofMicroorganisms · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Richard D TurnerDepartment of Respiratory Medicine, King's College Hospital.
Christopher ChiuSection of Infectious Diseases & Immunity, Imperial College London, United Kingdom.
Gavin J ChurchyardAurum Institute.
Hanif EsmailRadcliffe Department of Medicine, University of Oxford, United Kingdom.
David M LewinsohnDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland.
Neel R GandhiSchool of Medicine and Rollins School of Public Health, Emory University, Atlanta, Georgia.
Kevin P FennellyPulmonary Clinical Medicine Section, Cardiovascular Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Funding

Bronchiectasis and chronic airway infectionZIAHL006200 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FENNELLY, KEVIN · 2015 to 2025
$25.1M
Aurum Clinical Trials UnitUM1AI154463 · NIAID · AURUM INSTITUTE NPC · PI Gavin John Churchyard · 2021 to 2026
$8.1M
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
Medical Research Council G0902266NIAID NIH HHS K24 AI114444NIAID NIH HHS UM1 AI154463
6 · The paper itself

Abstract

The transmission of tuberculosis is complex. Necessary factors include a source case with respiratory disease that has developed sufficiently for Mycobacterium tuberculosis to be present in the airways. Viable bacilli must then be released as an aerosol via the respiratory tract of the source case. This is presumed to occur predominantly by coughing but may also happen by other means. Airborne bacilli must be capable of surviving in the external environment before inhalation into a new potential host-steps influenced by ambient conditions and crowding and by M. tuberculosis itself. Innate and adaptive host defenses will then influence whether new infection results; a process that is difficult to study owing to a paucity of animal models and an inability to measure infection directly. This review offers an overview of these steps and highlights the many gaps in knowledge that remain.

Indexed as

Disease SusceptibilityDisease Transmission, InfectiousHumansMycobacterium tuberculosisTuberculosisinfectiousnesssusceptibilitytransmissionTuberculosis

Identifiers

PMID29112746
PMCPMC5853924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.