Evidence map›Paper›PMID 29112744›Full record

ReviewThe Journal of infectious diseases2017

Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?

Sara C Auld, Anne G Kasmar, David W Dowdy, Barun Mathema, Neel R Gandhi, Gavin J Churchyard, Roxana Rustomjee, N Sarita Shah

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Role of casual contact in drug-resistant tuberculosis transmission: a molecular epidemiology study.American journal of respiratory and critical care medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Aerosolization ofAmerican journal of respiratory and critical care medicine · 2022
    Article
  10. Article
  11. Article
  12. Social Mixing and Clinical Features Linked With Transmission in a Network of Extensively Drug-resistant Tuberculosis Cases in KwaZulu-Natal, South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  13. Article
  14. Review
  15. A reevaluation of iron binding by Mycobactin J.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Sara C AuldSchool of Medicine and Rollins School of Public Health, Emory University.
Anne G KasmarBill and Melinda Gates Foundation, Seattle, Washington.
David W DowdyBloomberg School of Public Health, Johns Hopkins University, Baltimore.
Barun MathemaDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Neel R GandhiSchool of Medicine and Rollins School of Public Health, Emory University.
Gavin J ChurchyardAurum Institute and the School of Public Health, University of Witwatersrand.
Roxana RustomjeeDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
N Sarita ShahDivision of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.
Emory University · USAurum Institute · ZABill & Melinda Gates Foundation · USCenters for Disease Control and Prevention · USColumbia University · USJohns Hopkins University · USNational Institute of Allergy and Infectious Diseases · US

Funding

Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
Impact of HIV infection on early responses to TB exposureK23AI134182 · NIAID · EMORY UNIVERSITY · PI AULD, SARA · 2018 to 2023
$972k
Intramural CDC HHS CC999999NIAID NIH HHS K23 AI134182NIAID NIH HHS K24 AI114444
6 · The paper itself

Abstract

High rates of tuberculosis transmission are driving the ongoing global tuberculosis epidemic, and there is a pressing need for research focused on understanding and, ultimately, halting transmission. The ongoing tuberculosis-human immunodeficiency virus (HIV) coepidemic and rising rates of drug-resistant tuberculosis in parts of the world add further urgency to this work. Success in this research will require a concerted, multidisciplinary effort on the part of tuberculosis scientists, clinicians, programs, and funders and must span the research spectrum from biomedical sciences to the social sciences, public health, epidemiology, cost-effectiveness analyses, and operations research. Heterogeneity of tuberculosis disease, both among individual patients and among communities, poses a substantial challenge to efforts to interrupt transmission. As such, it is likely that effective interventions to stop transmission will require a combination of approaches that will vary across different epidemiologic settings. This research roadmap summarizes key gaps in our current understanding of transmission, as laid out in the preceding articles in this series. We also hope that it will be a call to action for the global tuberculosis community to make a sustained commitment to tuberculosis transmission science. Halting transmission today is an essential step on the path to end tuberculosis tomorrow.

Indexed as

Biomedical ResearchCommunicable Disease ControlDisease Transmission, InfectiousHumansTuberculosispublic healthtransmissiontuberculosis

Identifiers

PMID29112744
PMCPMC5793854
OpenAlexW2766800225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.