Evidence map›Paper›PMID 29112718›Full record

ArticleNucleic acids research2018

Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families.

Ioanna Kalvari, Joanna Argasinska, Natalia Quinones-Olvera, Eric P Nawrocki, Elena Rivas, Sean R Eddy, Alex Bateman, Robert D Finn, Anton I Petrov

Abstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 547 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
547citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

547 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Molecular Insights intoLife (Basel, Switzerland) · 2026
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487 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ioanna KalvariEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Joanna ArgasinskaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Natalia Quinones-OlveraSystems Biology Graduate Program, Harvard University, Cambridge, MA 02138, USA.
Eric P NawrockiNational Center for Biotechnology Information; National Institutes of Health; Department of Health and Human Services; Bethesda, MD 20894, USA.
Elena RivasDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Sean R EddyHoward Hughes Medical Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Alex BatemanEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Robert D FinnEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Anton I PetrovEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Funding

HMMER and Infernal: Finding distant homologs of sequences and RNA structuresR01HG009116 · NHGRI · HARVARD UNIVERSITY · PI EDDY, SEAN R · 2016 to 2025
$4.3M
Biotechnology and Biological Sciences Research Council BB/M011690/1NHGRI NIH HHS R01 HG009116
6 · The paper itself

Abstract

The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.

Indexed as

Databases, Nucleic AcidGenomeHumansMolecular Sequence AnnotationNucleic Acid ConformationRNA, UntranslatedSequence AlignmentSequence Analysis, RNARNA, Untranslated

Identifiers

PMID29112718
PMCPMC5753348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.