ArticleShock (Augusta, Ga.)2018
Baroreflex Sensitivity and Blood Pressure Variability can Help in Understanding the Different Response to Therapy During Acute Phase of Septic Shock.
Article in Shock (Augusta, Ga.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02141607 (Multiscale Approach to Describe the Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multiscale Approach to Describe the Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Blood pressure variability and its utility in acute disease and critical illness: a systematic review.BMC anesthesiology · 2025Pooled it
- Maximum heart rate and mortality in sepsis patients: a retrospective cohort study.Internal and emergency medicine · 2026Article
- The impacts of blood pressure variability on clinical outcomes in patients with out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
- A Comprehensive Review of Acute Type A Aortic Dissection: Epidemiology, Classification, Management Strategies, Mortality Risk Assessment, and Ethical Considerations for Patients who Refuse Blood Transfusions.Reviews in cardiovascular medicine · 2025Review
- Autonomic Function and Baroreflex Control in COVID-19 Patients Admitted to the Intensive Care Unit.Journal of clinical medicine · 2024Article
- Assessment of baroreflex sensitivity during isometric handgrip exercise and oscillatory lower body negative pressure.Journal of Taibah University Medical Sciences · 2023Article
- Article
- Beta-blockers in septic shock: What is new?Journal of intensive medicine · 2022Review
- Predictive Capacity of Beat-to-Beat Blood Pressure Variability for Cardioautonomic and Vascular Dysfunction in Early Metabolic Challenge.Frontiers in pharmacology · 2022Article
- Cerebral Autoregulation Indices Are Not Interchangeable in Patients With Sepsis.Frontiers in neurology · 2022Article
- The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrative review.Annals of intensive care · 2021Review
- Article
- Vascular Decoupling in Septic Shock: The Combined Role of Autonomic Nervous System, Arterial Stiffness, and Peripheral Vascular Tone.Frontiers in physiology · 2020Article
- Predicting adverse hemodynamic events in critically ill patients.Current opinion in critical care · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMean values of hemodynamic variables are poorly effective in evaluating an actual recovery of the short-term autonomic mechanisms for blood pressure (BP) and heart rate (HR) regulation. The aim of this work is to analyze the response to therapy in the early phase of septic shock to verify possible associations between BP recovery and BP autonomic control.
methodsThis is an ancillary study from the multicenter prospective observational trial Shockomics (NCT02141607). A total of 21 septic shock patients were studied at two time points during the acute phase of shock and were classified according to changes in SOFA score. Time series of BP components and HR were analyzed in time and frequency domain. Baroreflex sensitivity (BRS) was assessed, and a mathematical model for the decomposition of diastolic arterial pressure (DAP) oscillations was used to understand the different contributions of BRS and HR on peripheral vascular resistance control.
resultsOnly those patients, who significantly improved organ function (responders, R), showed an increase of mean value and low frequency (LF) power in BP time series. Fluid accumulation was higher in the non-responders (NR). BRS increased in NR and the model of DAP variability showed that the contribution of HR was highly reduced in NR.
conclusionsAlthough patients reached the mean BP target of 65 mmHg, our analyses highlighted important differences in terms of autonomic nervous system control. BP variability, HR variability and baroreflex trends can add information to individual vital sign measure such as mean BP, and can help in understanding the responsiveness to the combination of symphatomimetic drugs and fluid therapy.
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