Evidence map›Paper›PMID 29112462›Full record

ReviewHuman vaccines & immunotherapeutics2017

Cancer vaccines and immunotherapeutic approaches in hepatobiliary and pancreatic cancers.

Inga Hochnadel, Uta Kossatz-Boehlert, Nils Jedicke, Henrike Lenzen, Michael P Manns, Tetyana Yevsa

Open access · bronzeAbstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. A new antisarcoma strategy: multisubtype heat shock protein/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Inga Hochnadela Department of Gastroenterology , Hepatology and Endocrinology, Hannover Medical School , Hannover , Germany.
Uta Kossatz-Boehlertb Institute for Neuroanatomy, Eberhard-Karls University Tuebingen , Tuebingen , Germany.
Nils Jedickea Department of Gastroenterology , Hepatology and Endocrinology, Hannover Medical School , Hannover , Germany.
Henrike Lenzena Department of Gastroenterology , Hepatology and Endocrinology, Hannover Medical School , Hannover , Germany.
Michael P Mannsa Department of Gastroenterology , Hepatology and Endocrinology, Hannover Medical School , Hannover , Germany.
Tetyana Yevsaa Department of Gastroenterology , Hepatology and Endocrinology, Hannover Medical School , Hannover , Germany.
Medizinische Hochschule Hannover · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatobiliary and pancreatic cancers along with other gastrointestinal malignancies remain the leading cause of cancer-related deaths worldwide. Strategies developed in the recent years on immunotherapy and cancer vaccines in the setting of primary liver cancer as well as in pancreatic cancer are the scope of this review. Significance of orthotopic and autochthonous animal models which mimic and/or closely reflect human malignancies allowing for a prompt and trustworthy analysis of new therapeutics is underlined. Combinational approaches that on one hand, specifically target a defined cancer-driving pathway, and on the other hand, restore the functions of immune cells, which effector functions are often suppressed by a tumor milieu, are shown to have the strongest perspectives and future directions. Among combinational immunotherapeutic approaches a personalized- and individual cancer case-based therapy is of special importance.

Indexed as

AnimalsCancer VaccinesDisease Models, AnimalDrug DiscoveryHumansImmunotherapyLiver NeoplasmsPancreatic NeoplasmsCancer Vaccinescancer vaccinescholangiocarcinomagastrointestinal cancerhepatocellular carcinomaimmunotherapypancreatic ductal adenocarcinoma

Identifiers

PMID29112462
PMCPMC5718787
OpenAlexW2767904212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.