Evidence map›Paper›PMID 29112074›Full record

ArticleAIDS (London, England)2018

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.

Kristin Beima-Sofie, Dalton Wamalwa, Elizabeth Maleche-Obimbo, Jairam R Lingappa, Romel Mackelprang, Soren Gantt, Grace John-Stewart, Corey Casper, Jennifer A Slyker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Kristin Beima-SofieDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Dalton WamalwaDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Elizabeth Maleche-ObimboDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Jairam R LingappaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Romel MackelprangDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Soren GanttUniversity of British Columbia, BC Children's Hospital, Vancouver, British Columbia, Canada.
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Corey CasperDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Jennifer A SlykerDepartment of Global Health, University of Washington, Seattle, Washington, USA.
University of Washington · USUniversity of Nairobi · KEGTx (United States) · USUniversity of British Columbia · CA

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Project 3U54CA190146 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CASPER, COREY · 2014 to 2019
$4.1M
Institute of Translational Health SciencesTL1TR000422 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$2.1M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Vertical CMV transmission in the setting of maternal HIV-1 infection in KenyaK01AI087369 · NIAID · UNIVERSITY OF WASHINGTON · PI SLYKER, JENNIFER ANN · 2010 to 2014
$616k
Host Genetic Factors in the HIV Virus Life-Cycle and HIV Disease ProgressionR21AI073115 · NIAID · UNIVERSITY OF WASHINGTON · PI LINGAPPA, JAIRAM RAO · 2007 to 2008
$426k
FIC NIH HHS R24 TW007988NCATS NIH HHS TL1 TR000422NCATS NIH HHS TL1 TR002318NCI NIH HHS U54 CA190146NIAID NIH HHS K01 AI087369NIAID NIH HHS P30 AI027757NIAID NIH HHS R21 AI073115NICHD NIH HHS K24 HD054314NICHD NIH HHS R01 HD023412
6 · The paper itself

Abstract

: Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio = 4.2, P = 0.02) compared with 1635GG. In addition, 1635A was associated with 0.4 log10 copies/ml lower median EBV levels in HIV-infected infants (P = 0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.

Indexed as

Genetic Predisposition to DiseaseCohort StudiesCytomegalovirus InfectionsEpstein-Barr Virus InfectionsFemaleGene FrequencyHIV InfectionsHumansInfantKenyaMaleToll-Like Receptor 9Toll-Like Receptor 9

Identifiers

PMID29112074
PMCPMC5736409
OpenAlexW2767522183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.