ArticleeLife2017
Otoferlin acts as a Ca
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07778641 (Genetic Study of OTOF- Related Auditory Neuropathy Spectrum Disorder), which is not on this map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Study of OTOF- Related Auditory Neuropathy Spectrum Disorder
Who cites it
72 citing papers in PubMed, 143 citations in OpenAlex.
- Efficacy and safety of SENS-501, a dual-AAV otoferlin gene therapy, for DFNB9 congenital deafness.Molecular therapy. Advances · 2026Article
- Spectrum of DNA Variants Underlying Deafness in an Ecuadorian Cohort.Biochemical genetics · 2026Article
- Early life visceral stress induces auditory brainstem sensitization and cochlear proteomic alterations in a rat model of irritable bowel syndrome.Neurobiology of stress · 2026Article
- Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness.Nature communications · 2026Article
- Patterned pre-sensory spontaneous activity drives the structural refinement of developing cochlear ribbon synapses.Frontiers in synaptic neuroscience · 2026Article
- Hair cell loss - cause or consequence of hearing loss?Frontiers in cell and developmental biology · 2026Review
- Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy.Science advances · 2025Article
- Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing.Science advances · 2025Article
- Structural insights into lipid membrane binding by human ferlins.The EMBO journal · 2025Article
- Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model.Communications medicine · 2025Article
- Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- SIRT1 prevents noise-induced hearing loss by enhancing cochlear mitochondrial function.Cell communication and signaling : CCS · 2025Article
- UtilizingJournal of developmental biology · 2025Review
- The Role of Calcium Signaling in Sensorineural Hearing Loss.International journal of medical sciences · 2025Review
- Article
- DMXL2 Is Required for Endocytosis and Recycling of Synaptic Vesicles in Auditory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis.Scientific reports · 2024Article
- Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.Protein & cell · 2024Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The natural history, clinical outcomes, and genotype-phenotype relationship of otoferlin-related hearing loss: a systematic, quantitative literature review.Human genetics · 2023Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 9 institutions in 4 countries.
Nicolas MichalskiUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-1287-2709
Juan D GoutmanInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
Sarah Marie AuclairDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.
Jacques Boutet de MonvelUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0001-6182-3527
Margot TertraisUMRS 1120, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Alice EmptozUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.
Alexandre ParrinUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.
Sylvie NouailleUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.
Marc GuillonWave Front Engineering Microscopy Group, Neurophotonics Laboratory, Centre National de la Recherche Scientifique, UMR 8250, University Paris Descartes, Sorbonne Paris Cité, Paris, France.
Martin SachseCenter for Innovation & Technological Research, Ultrapole, Institut Pasteur, Paris, France.
Danica CiricUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-0098-6258
Amel BahloulUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0001-7042-4616
Jean-Pierre HardelinUnité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-1815-7909
Roger Bryan SuttonDepartment of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, United States.
Paul AvanLaboratoire de Biophysique Sensorielle, Université Clermont Auvergne, Clermont-Ferrand, France.
Shyam S KrishnakumarDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID http://orcid.org/0000-0001-6148-3251
James E RothmanDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID http://orcid.org/0000-0001-8653-8650
Didier Dulon *UMRS 1120, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Saaid Safieddine *Unité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-6159-0572
Christine Petit *Unité de Génétique et Physiologie de l'Audition, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-9069-002X
Inserm · FRYale University · USCentre National de la Recherche Scientifique · FRUniversité de Bordeaux · FRConsejo Nacional de Investigaciones Científicas y Técnicas · ARDélégation Paris 5 · FRInstitut de la Vision · FRInstitut Pasteur · FRTexas Tech University · US
Funding
Human dysferlin and its implications in Limb-Girdle Muscular DystrophyR01AR063634 · NIAMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI SUTTON, ROGER BRYAN · 2014 to 2018
$1.8MNIAMS NIH HHS R01 AR063634
Abstract
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C
Indexed as
Membrane FusionAnimalsCalciumGene Knock-In TechniquesHair Cells, AuditoryMembrane ProteinsMiceProtein BindingReceptors, Calcium-SensingSynapsesSynaptic VesiclesCalciumMembrane Proteinsotoferlin protein, mouseReceptors, Calcium-Sensingdeafnessinner hair cellmouseneuroscienceneurotransmitter releasesynaptic exocytotic machinerysynaptopathytemporal precision
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07778641ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.