ArticleMicrobiology (Reading, England)2018
A phylogenetic and evolutionary analysis of antimycin biosynthesis.
Article in Microbiology (Reading, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Fermentation conditions outweigh phylogeny in shaping the metabolome of novelApplied and environmental microbiology · 2026Article
- The undiscovered natural product potential of Actinomycetes.The Journal of antibiotics · 2026Article
- Genomic Exploration of a ChitinolyticCurrent issues in molecular biology · 2024Article
- Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity.Applied and environmental microbiology · 2024Article
- Diversity and bioactive potential of Actinomycetia from the rhizosphere soil of Juniperus excelsa.Folia microbiologica · 2023Article
- The evolution of morphological development is congruent with the species phylogeny in the genusFrontiers in microbiology · 2023Article
- Ancient Antibiotics, Ancient Resistance.EcoSal Plus · 2021Review
- Chemical Ecology ofMicroorganisms · 2020Article
- Ecology and genomics of Actinobacteria: new concepts for natural product discovery.Nature reviews. Microbiology · 2020Review
- Comparative genomics of Alexander Fleming's original Penicillium isolate (IMI 15378) reveals sequence divergence of penicillin synthesis genes.Scientific reports · 2020Article
- Advances in actinomycete research: an ActinoBase review of 2019.Microbiology (Reading, England) · 2020Review
- Negative Correlation between Lipid Content and Antibiotic Activity inAntibiotics (Basel, Switzerland) · 2020Article
- A Hierarchical Network of Four Regulatory Genes Controlling Production of the Polyene Antibiotic Candicidin inApplied and environmental microbiology · 2020Article
- Article
- A chromatogram-simplified Streptomyces albus host for heterologous production of natural products.Antonie van Leeuwenhoek · 2020Article
- Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance.Nature microbiology · 2019Article
- Comparative Genomics among Closely RelatedAntibiotics (Basel, Switzerland) · 2018Article
- Article
- Antimycin A Improves Heat Tolerance in Creeping Bentgrass by Suppressing Nighttime Respiration and Reprogramming Carbon and Nitrogen Metabolism.Physiologia plantarumArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces species and other Actinobacteria are ubiquitous in diverse environments worldwide and are the source of, or inspiration for, the majority of antibiotics. The genomic era has enhanced biosynthetic understanding of these valuable chemical entities and has also provided a window into the diversity and distribution of natural product biosynthetic gene clusters. Antimycin is an inhibitor of mitochondrial cytochrome c reductase and more recently was shown to inhibit Bcl-2/Bcl-XL-related anti-apoptotic proteins commonly overproduced by cancerous cells. Here we identify 73 putative antimycin biosynthetic gene clusters (BGCs) in publicly available genome sequences of Actinobacteria and classify them based on the presence or absence of cluster-situated genes antP and antQ, which encode a kynureninase and a phosphopantetheinyl transferase (PPTase), respectively. The majority of BGCs possess either both antP and antQ (L-form) or neither (S-form), while a minority of them lack either antP or antQ (IQ- or IP-form, respectively). We also evaluate the biogeographical distribution and phylogenetic relationships of antimycin producers and BGCs. We show that antimycin BGCs occur on five of the seven continents and are frequently isolated from plants and other higher organisms. We also provide evidence for two distinct phylogenetic clades of antimycin producers and gene clusters, which delineate S-form from L- and I-form BGCs. Finally, our findings suggest that the ancestral antimycin producer harboured an L-form gene cluster which was primarily propagated by vertical transmission and subsequently diversified into S-, IQ- and IP-form biosynthetic pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.