ArticleNeurobiology of aging2018
Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease.Alzheimer's research & therapy · 2024Trial
- Machine learning for missing data imputation in Alzheimer's research: predicting medial temporal lobe dynamic flexibility.Cognitive neurodynamics · 2026Article
- Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study.Alzheimer's research & therapy · 2025Article
- Low premorbid IQ may exacerbate the cognitive effects of apolipoprotein ε4 (APOE ε4): a multi-ethnic cross-sectional study from HABS-HD.Frontiers in neurology · 2025Article
- Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PET.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly.Alzheimer's research & therapy · 2023Article
- Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease.Neurobiology of aging · 2022Article
- ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease - Study Protocol and Baseline Characteristics.Frontiers in neurology · 2022Article
- Comparison of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Partial volume correction analysis forNeuroImage · 2021Review
- Article
- Relationship between regional gray matter volumes and dopamine DHuman brain mapping · 2021Article
- Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [Alzheimer's research & therapy · 2021Article
- Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories.Neurobiology of aging · 2020Article
- In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- PET imaging of mGluR5 in Alzheimer's disease.Alzheimer's research & therapy · 2020Article
- An update on magnetic resonance imaging markers in AD.Therapeutic advances in neurological disorders · 2020Review
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Models of preclinical Alzheimer's disease (AD) propose that cerebral amyloidosis leads to neurodegeneration and subsequent cognitive decline. This study investigated whether APOE genotype is related to β-amyloid (Aβ) burden in brain regions preferentially affected by AD and whether Aβ burden is associated with gray-matter (GM) fraction (as a marker of neurodegeneration) and episodic memory performance in cognitively normal middle-aged individuals at varying genetic risk for AD. Three groups of cognitively normal participants aged 50-65 years with a first-degree family history of AD (APOE genotype ε4ε4 [n = 15], ε3ε4 [n = 15], and ε3ε3 [n = 15]) underwent [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.