ArticleProgress in neuro-psychopharmacology & biological psychiatry2018
Investigation of superior longitudinal fasciculus fiber complexity in recent onset psychosis.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Detection of white matter microstructural changes in patients with systemic lupus erythematosus based on multiple diffusion models and related diffusion metrics.Neural regeneration research · 2026Article
- Structural network disruption of corticothalamic pathways in cerebral small vessel disease.Brain imaging and behavior · 2024Article
- Structural impairment in superficial and deep white matter in schizophrenia.Acta neuropsychiatrica · 2023Article
- Association between white matter microstructure and cognitive function in patients with methamphetamine use disorder.Human brain mapping · 2023Article
- Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia.Brain sciences · 2022Article
- Segmental abnormalities of superior longitudinal fasciculus microstructure in patients with schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder: An automated fiber quantification tractography study.Frontiers in psychiatry · 2022Article
- Disturbances in White Matter Integrity in the Ultra-High-Risk Psychosis State-A Systematic Review.Journal of clinical medicine · 2021Review
- Generalized neurocognitive impairment in individuals at ultra-high risk for psychosis: The possible key role of slowed processing speed.Brain and behavior · 2021Article
- White Matter Correlates of Theory of Mind in Patients With First-Episode Psychosis.Frontiers in psychiatry · 2021Article
- Respirator usage protects brain white matter from welding fume exposure: A pilot magnetic resonance imaging study of welders.Neurotoxicology · 2020Article
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundStandard diffusion tensor imaging measures (e.g., fractional anisotropy; FA) are difficult to interpret in brain regions with crossing white-matter (WM) fibers. Diffusion spectrum imaging (DSI) can be used to resolve fiber crossing, but has been difficult to implement in studies of patients with psychosis given long scan times.
methodsWe used four fold accelerated compressed sensing to accelerate DSI acquisition to investigate the superior longitudinal fasciculus (SLF) in 27 (20M/7F) patients with recent onset psychosis and 23 (11M/12F) healthy volunteers. Dependent measures included the number of crossing fiber directions, multi directional anisotropy (MDA), which is a measure sensitive to the anisotropy of the underlying water diffusion in regions of crossing fibers, generalized FA (GFA) computed from the orientation distribution function, FA and tract volume.
resultsPatients demonstrated a greater number of crossing WM fibers, lower MDA, GFA and FA in the left SLF compared to healthy volunteers. Patients also demonstrated a reversal in the normal (R>L) asymmetry of crossing fiber directions in the SLF and a lack of normal (L>R) asymmetry in MDA, GFA and FA compared to healthy volunteers. Lower GFA correlated significantly (p<0.05) with worse overall neuropsychological functioning; posthoc tests revealed significant effects with verbal functioning and processing speed.
conclusionsOur findings provide the first in vivo evidence for abnormal crossing fibers within the SLF among individuals with psychosis and their functional correlates. A reversal in the normal pattern of WM asymmetry of crossing fibers in patients may be consistent with an aberrant neurodevelopmental process.
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