ArticleHormones and behavior2018
Mating and social exposure induces an opioid-dependent conditioned place preference in male but not in female prairie voles (Microtus ochrogaster).
Article in Hormones and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Paternal Deprivation Alters Neural Stem Cells Proliferation and Epigenetic Histone Modifications in the Neurogenic Niches of Adult Prairie Voles.International journal of molecular sciences · 2026Article
- Article
- Pair bond quality influences social conditioned place preference expression, passive coping behavior, and central oxytocin receptor expression following partner loss in male prairie voles.Social neuroscience · 2024Article
- Nucleus accumbens dopamine release reflects the selective nature of pair bonds.Current biology : CB · 2024Article
- Article
- Sex differences in the reward value of familiar mates in prairie voles.Genes, brain, and behavior · 2022Article
- The neural circuits of monogamous behavior.Frontiers in neural circuits · 2022Review
- Pair-bonding and social experience modulate new neurons survival in adult male and female prairie voles (Frontiers in neuroanatomy · 2022Article
- Selectivity and Sociality: Aggression and Affiliation Shape Vole Social Relationships.Frontiers in behavioral neuroscience · 2022Review
- Article
- Raised without a father: monoparental care effects over development, sexual behavior, sexual reward, and pair bonding in prairie voles.Behavioural brain research · 2021Article
- The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation.Current opinion in neurobiology · 2021Review
- Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia.Endocrinology · 2021Review
- Article
- Repeated Paced Mating Increases the Survival of New Neurons in the Accessory Olfactory Bulb.Frontiers in neuroscience · 2020Article
- Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Neural plasticity · 2020Article
- Comparative role of reward in long-term peer and mate relationships in voles.Hormones and behavior · 2019Article
- Motivational Drive in Non-copulating and Socially Monogamous Mammals.Frontiers in behavioral neuroscience · 2019Article
- Effect of reward type on object discrimination learning in socially monogamous coppery titi monkeys (Callicebus cupreus).American journal of primatology · 2018Article
- Resting state brain networks in the prairie vole.Scientific reports · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
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Abstract
In rodents, sexual stimulation induces a positive affective state that is evaluated by the conditioned place preference (CPP) test. Opioids are released during sexual behavior and modulate the rewarding properties of this behavior. Prairie voles (Microtus ochrogaster) are a socially monogamous species, in which copulation with cohabitation for 6h induces a pair bond. However, the mating-induced reward state that could contribute to the establishment of the long-term pair bond has not been evaluated in this species. The present study aimed to determine whether one ejaculation or cohabitation with mating for 6h is rewarding for voles. We also evaluated whether this state is opioid dependent. Our results demonstrate that mating with one ejaculation and social cohabitation with mating for 6h induce a CPP in males, while exposure to a sexually receptive female without mating did not induce CPP. In the female vole, mating until one ejaculation, social cohabitation with mating, or exposure to a male without physical interaction for 6h did not induce CPP. To evaluate whether the rewarding state in males is opioid dependent, the antagonist naloxone was injected i.p. The administration of naloxone blocked the rewarding state induced by one ejaculation and by social cohabitation with mating. Our results demonstrate that in the prairie vole, on the basis of the CPP in the testing conditions used here, the stimulation received with one ejaculation and the mating conditions that lead to pair bonding formation may be rewarding for males, and this reward state is opioid dependent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.