ArticleThe Journal of allergy and clinical immunology2018
Prenatal and early-life triclosan and paraben exposure and allergic outcomes.
Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Itching to know: the Microbiome, Allergic Disease, and Antimicrobial Chemicals.Current environmental health reports · 2026Review
- Exposure to Urinary and Dust Parabens: Compound-Specific Risks for Pediatric Respiratory Allergic Phenotypes.Toxics · 2026Article
- Environmental Pollutants and Food Allergy: From Traditional Triggers to Emerging Hazards.Clinical reviews in allergy & immunology · 2026Review
- Field cancerization, accelerated aging, and immunosuppression: the rapid rise of hormone-sensitive and early-onset breast cancer.NPJ breast cancer · 2025Review
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort.Journal of exposure science & environmental epidemiology · 2025Article
- Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice.Nature communications · 2025Article
- Early-life exposure to a mixture of phenols and respiratory health in preschool children.The European respiratory journal · 2025Article
- Paraben exposure related to Staphylococcal enterotoxin IgE sensitization, allergic rhinitis and nasal patency in children.Scientific reports · 2025Article
- The association between environmental endocrine-disrupting chemicals and allergic disorders in children: A comprehensive systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Association between urinary exposures and the risk of chronic obstructive pulmonary disease in smokers: results from NHANES 2007-2016.Frontiers in public health · 2025Article
- Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study.International journal of hygiene and environmental health · 2024Article
- Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma.Current environmental health reports · 2023Review
- Asthma and Environmental Exposures to Phenols, Polycyclic Aromatic Hydrocarbons, and Phthalates in Children.Current environmental health reports · 2023Article
- Adverse effects of triclosan exposure on health and potential molecular mechanisms.The Science of the total environment · 2023Review
- Chronic application of alcohol-soluble gluten extract over undamaged skin causes clinical sensitization for life-threatening anaphylaxis via activation of systemic Th2 immune responses in mice.Frontiers in allergy · 2023Article
- Increased Prevalence of Atopic Dermatitis in Children Aged 0-3 Years Highly Exposed to Parabens.International journal of environmental research and public health · 2021Article
- Chemical Exposures via Personal Care Products and the Disproportionate Asthma Burden Among the U.S. Black Population.The journal of allergy and clinical immunology. In practice · 2021Article
- Review
- Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study.Environmental health : a global access science source · 2021Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundIn cross-sectional studies triclosan and parabens, ubiquitous ingredients in personal care and other products, are associated with allergic disease.
objectivesWe investigated the association between prenatal and early-life triclosan and paraben exposure and childhood allergic disease in a prospective longitudinal study.
methodsSubjects were enrollees in the Vitamin D Antenatal Asthma Reduction Trial. Triclosan, methyl paraben, and propyl paraben concentrations were quantified in maternal plasma samples pooled from the first and third trimesters and urine samples from children at age 3 or 4 years. Outcomes were parental report of physician-diagnosed asthma or recurrent wheezing and allergic sensitization to food or environmental antigens based on serum specific IgE levels at age 3 years in high-risk children.
resultsThe analysis included 467 mother-child pairs. Overall, there were no statistically significant associations of maternal plasma or child urine triclosan or paraben concentrations with asthma or recurrent wheeze or food or environmental sensitization at age 3 years. A trend toward an inverse association between triclosan and paraben exposure and allergic sensitization was observed. There was evidence of effect measure modification by sex, with higher odds of environmental sensitization associated with increasing paraben concentrations in male compared with female subjects.
conclusionsWe did not identify a consistent association between prenatal and early-life triclosan or paraben concentrations and childhood asthma, recurrent wheeze, or allergic sensitization in the overall study population. The differential effects of triclosan or paraben exposure on allergic sensitization by sex observed in this study warrant further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.