Evidence map›Paper›PMID 29111212›Full record

ArticleThe Journal of allergy and clinical immunology2018

Monocyte chemotactic protein-induced protein 1 controls allergic airway inflammation by suppressing IL-5-producing T

Hui Peng, Huan Ning, Qinghong Wang, Wenbao Lu, Yingzi Chang, Tony T Wang, Jinping Lai, Pappachan E Kolattukudy, Rong Hou, Daniel F Hoft and 2 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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  12. Deletion of Mcpip1 in Mcpip1Biochimica et biophysica acta. Molecular basis of disease · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Hui PengDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Huan NingDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Qinghong WangDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Wenbao LuDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Yingzi ChangPharmacology Department, A.T. Still University, Kirksville, Mo.
Tony T WangSRI International, Harrisonburg, Va.
Jinping LaiDepartment of Pathology, Saint Louis University School of Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Pappachan E KolattukudyBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Fla.
Rong HouDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Daniel F HoftDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Mark S DykewiczDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo.
Jianguo LiuDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo. Electronic address: jianguo.liu@health.slu.edu.
Saint Louis University · USA.T. Still University · USSRI International · USUCLouvain Saint-Louis Brussels · BEUniversity of Central Florida · US

Funding

Tight Junction: Gate to HCV Tropism, Therapeutics and PathogenesisR01DK088787 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEIN, PAUL L · 2010 to 2019
$4.2M
The role of tristetraprolin in control of breast cancer progressionR01CA163808 · NCI · SAINT LOUIS UNIVERSITY · PI LIU, JIANGUO · 2012 to 2016
$1.5M
NCI NIH HHS R01 CA163808NIDDK NIH HHS R01 DK088787
6 · The paper itself

Abstract

backgroundAsthmatic and allergic inflammation is mediated by T

objectivesIn this study we investigate how monocyte chemotactic protein-induced protein 1 (MCPIP1; encoded by the Zc3h12a gene) regulates IL-5-producing T

methodsThe functions of Zc3h12a

resultsZc3h12a

conclusionsOur study reveals that MCPIP1 regulates the development and function of IL-5-producing T

Indexed as

Adoptive TransferAnimalsAsthmaCell DifferentiationCells, CulturedDisease Models, AnimalGATA3 Transcription FactorHumansImmunosuppression TherapyInflammationInterleukin-13Interleukin-5MiceMice, Inbred C57BLMice, KnockoutReceptors, NotchGata3 protein, mouseGATA3 Transcription FactorInterleukin-13Interleukin-5Receptors, NotchRibonucleasesZc3h12a protein, mouseasthmaGata3IL-13IL-4IL-5MCPIP1mRNA decayNotchRNA-Binding proteinT(H)2 cells

Identifiers

PMID29111212
PMCPMC5924426
OpenAlexW2766961286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.