Evidence map›Paper›PMID 29111178›Full record

ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2018

Dose-dependent neurocognitive deficits following postnatal day 10 HIV-1 viral protein exposure: Relationship to hippocampal anatomy parameters.

Sylvia Fitting, Kristen A McLaurin, Rosemarie M Booze, Charles F Mactutus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Emerging Role of Nef in the Development of HIV Associated Neurological Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sylvia FittingUniversity of South Carolina, Behavioral Neuroscience Program, Department of Psychology, Columbia, SC 29208, USA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: sfitting@email.unc.edu.
Kristen A McLaurinUniversity of South Carolina, Behavioral Neuroscience Program, Department of Psychology, Columbia, SC 29208, USA.
Rosemarie M BoozeUniversity of South Carolina, Behavioral Neuroscience Program, Department of Psychology, Columbia, SC 29208, USA.
Charles F MactutusUniversity of South Carolina, Behavioral Neuroscience Program, Department of Psychology, Columbia, SC 29208, USA. Electronic address: mactutus@mailbox.sc.edu.
University of South Carolina · USUniversity of North Carolina at Chapel Hill · US

Funding

HIV/COCAINE NEUROTOXICITY IN FEMALESR01DA013137 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOOZE, ROSEMARIE M, MACTUTUS, CHARLES F. · 2000 to 2021
$7.7M
Maternal HIV: Developmental Neurotoxicity - Administrative SupplementR01HD043680 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOOZE, ROSEMARIE M, MACTUTUS, CHARLES F. · 2003 to 2016
$2.8M
Progression of Attentional and Executive Function Deficits in HANDR01MH106392 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOOZE, ROSEMARIE M, MACTUTUS, CHARLES F. · 2016 to 2020
$1.8M
Neurobiological Mechanisms of Apathy in HANDR01NS100624 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOOZE, ROSEMARIE M, MACTUTUS, CHARLES F. · 2017 to 2021
$1.8M
Opiate drug abuse & HIV-induced excitotoxicity in striatal neuronsR00DA033878 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FITTING, SYLVIA · 2015 to 2017
$745k
NICHD NIH HHS R01 HD043680NIDA NIH HHS R00 DA033878NIDA NIH HHS R01 DA013137NIMH NIH HHS R01 MH106392NINDS NIH HHS R01 NS100624
6 · The paper itself

Abstract

Despite the availability of antiretroviral prophylactic treatment, pediatric human immunodeficiency virus type 1 (HIV-1) continues to be a significant risk factor in the post-cART era. The time of infection (i.e., during pregnancy, delivery or breastfeeding) may play a role in the development of neurocognitive deficits in pediatric HIV-1. HIV-1 viral protein exposure on postnatal day (P)1, preceding the postnatal brain growth spurt in rats, had deleterious effects on neurocognitive development and anatomical parameters of the hippocampus (Fitting et al., 2008a,b). In the present study, rats were stereotaxically injected with HIV-1 viral proteins, including Tat

Indexed as

Age FactorsAnalysis of VarianceAnimalsAnimals, NewbornCognition DisordersDisease Models, AnimalDose-Response Relationship, DrugGait Disorders, NeurologicHippocampusHIV Envelope Protein gp120HumansMovement DisordersNeurodevelopmental DisordersNeurogliaNeuronsRatsHIV Envelope Protein gp120Gp120HippocampusPediatric HIV-1Spatial learningStereologyTat

Identifiers

PMID29111178
PMCPMC5889695
OpenAlexW2766897638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.