Evidence map›Paper›PMID 29111168›Full record

ArticleIndian pacing and electrophysiology journal

Standardized programming to reduce the burden of inappropriate therapies in implantable cardioverter defibrillators - Single centre follow up results.

U Boles, E E Gul, L Fitzgerald, F Sadiq Ali, C Nolan, K Aldworth-Gaumond, D R Redfearn, A Baranchuk, B Glover, C Simpson and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Indian pacing and electrophysiology journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04344704 (Prevention of Inappropriate Therapies and Serious Adverse Cardiac and Cerebrovascular Events With a Single Chamber Implantable Cardioverter Defibrillator), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04344704 unknown statusnot on this map

Prevention of Inappropriate Therapies and Serious Adverse Cardiac and Cerebrovascular Events With a Single Chamber Implantable Cardioverter Defibrillator (ICD) With DX Floating Dipole Detection. PREVENT DX

Typeobservational_patient_registrySponsorTrialance SCCLRan2018 to 2023Enrolled462ConditionsPrevention of Inappropriate Therapies and MACCE. Single-chamber ICDArmsSingle chamber DAI device with floating atrial dipole
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Programming an ICD: It's time to change the defaults.Indian pacing and electrophysiology journal
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

U BolesHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada; Cardiology Department, Midland Regional Hospital Mullingar (MRHM), Ireland. Electronic address: bolesu@tcd.ie.
E E GulHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
L FitzgeraldCardiology Department, Midland Regional Hospital Mullingar (MRHM), Ireland.
F Sadiq AliHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
C NolanHeart and Vascular Centre, Mater Private Hospital, Dublin, Ireland.
K Aldworth-GaumondHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
D R RedfearnHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
A BaranchukHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
B GloverHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
C SimpsonHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
H AbdollahHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.
K A MichaelHeart Rhythm Service, Division of Cardiology, Kingston General Hospital, Queen's University, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent algorithms and device morphology templates have been proposed in current Implantable Cardioverter-Defibrillators (ICDs) to minimize inappropriate therapies (ITS), but this has not been completely successful.

aimAssess the impact of a deliberate strategy of using an atrial lead implant with standardized parameters; based on all current ICD discriminators and technologies, on the burden of ITS.

methodA retrospective single-centre analysis of 250 patients with either dual chamber (DR) ICDs or biventricular ICDs (CRTDs) over a (41.9 ± 27.3) month period was performed. The incidence of ITS on all ICD and CRTD patients was chronicled after the implementation of standardized programming.

results39 events of anti-tachycardial pacing (ATP) and/or shocks were identified in 20 patients (8% incidence rate among patients). The total number of individual therapies was 120, of which 34% were inappropriate ATP, and 36% were inappropriate shocks. 11 patients of the 250 patients received ITS (4.4%). Of the 20 patients, four had ICDs for primary prevention and 16 for a secondary prevention. All the episodes in the primary indication group were inappropriate, while seven patients (43%) of the secondary indication group experienced inappropriate therapies.

conclusionsThe burden of ITS in the population of patients receiving ICDs was 4.4% in the presence of atrial leads. The proposed rationalized programming criteria seems an effective strategy to minimize the burden of inappropriate therapies and will require further validation.

Indexed as

Implantable cardioverter-defibrillator (ICDs)Inappropriate therapiesStandardized programming

Identifiers

PMID29111168
PMCPMC5998837

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.