ReviewJournal of the neurological sciences2017
Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities.
Review in Journal of the neurological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.Genome medicine · 2024Pooled it
- Pooled it
- Identification of novel biomarkers in ischemic stroke: a genome-wide integrated analysis.BMC medical genetics · 2020Pooled it
- Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.Journal of the neurological sciences · 2019Pooled it
- Randomized Trial of an Intervention to Improve Blood Pressure Control in Stroke Survivors.Circulation. Cardiovascular quality and outcomes · 2019Trial
- Driving Global Health equity and precision medicine through African genomic data.Human molecular genetics · 2025Article
- Developing a strategic action plan for reducing the burden of stroke in Africa: report of the first African Stroke Leaders' Summit.Frontiers in stroke · 2025Article
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Big Data in Stroke: How to Use Big Data to Make the Next Management Decision.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Stroke in Africa: profile, progress, prospects and priorities.Nature reviews. Neurology · 2021Review
- Biomarker Application for Precision Medicine in Stroke.Translational stroke research · 2020Review
- Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa.Brain research bulletin · 2019Review
- Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study.International journal of stroke : official journal of the International Stroke Society · 2019Article
- Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project.Biopreservation and biobanking · 2018Article
- New approaches to genetic predisposition for hemorrhagic stroke in sickle cell disease.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Unraveling the Ethical, Legal, and Social Implications of Neurobiobanking and Stroke Genomic Research in Africa: A Study Protocol of the African Neurobiobank for Precision Stroke Medicine ELSI Project.International journal of qualitative methodsArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundWe systematically reviewed the genetic variants associated with stroke in genome-wide association studies (GWAS) and examined the emerging priorities and opportunities for rapidly advancing stroke research in the era of Trans-Omics science.
methodsUsing the PRISMA guideline, we searched PubMed and NHGRI- EBI GWAS catalog for stroke studies from 2007 till May 2017.
resultsWe included 31 studies. The major challenge is that the few validated variants could not account for the full genetic risk of stroke and have not been translated for clinical use. None of the studies included continental Africans. Genomic study of stroke among Africans presents a unique opportunity for the discovery, validation, functional annotation, Trans-Omics study and translation of genomic determinants of stroke with implications for global populations. This is because all humans originated from Africa, a continent with a unique genomic architecture and a distinctive epidemiology of stroke; as well as substantially higher heritability and resolution of fine mapping of stroke genes.
conclusionUnderstanding the genomic determinants of stroke and the corresponding molecular mechanisms will revolutionize the development of a new set of precise biomarkers for stroke prediction, diagnosis and prognostic estimates as well as personalized interventions for reducing the global burden of stroke.
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